4.9 β’ 806 Ratings
ποΈ 2 January 2025
β±οΈ 19 minutes
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0:00.0 | I guess there's a gene therapy out there where you introduce a vector to somebody and |
0:07.7 | you, I don't think you fully silence, but you clearly attenuate, actually, no, I'm sorry, |
0:13.7 | you activate the gene for phallostatin. |
0:15.8 | That makes more of the phallostatin protein, which inhibits the expression of the myostatin gene, or maybe inhibits the protein myostatin, one or the other. |
0:27.7 | And this, of course, is theoretically interesting because of what we know about the actions of myostatin. |
0:36.2 | When I think back to images that stand out from my first year of medical school, clearly on the top 10 list. |
0:43.9 | You haven't even said it. |
0:44.7 | I already know what you're talking about. |
0:45.5 | Yeah, you know what I'm talking about, right? |
0:46.7 | This is still like more than 25 years ago. |
0:49.3 | I still remember sitting in class when they showed the myostatin knockout mice and cattle. |
0:56.2 | And do you want to just tell people what a myostatin knockout looks like? |
1:00.1 | Yeah. |
1:00.4 | So it produces a double muscle phenotype is what they call it. |
1:04.4 | And if you look at these cattle, it's like you would think it's Photoshop by how absurd it |
1:08.5 | looks. |
1:08.8 | This is like the Mr. |
1:09.7 | Olympia of cattle essentially. |
1:11.8 | Like it would be no chance. |
1:13.1 | Anyone would come close in, |
1:14.4 | you know, |
1:14.7 | cattle sport. |
... |
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