A very volcanic moon, and better protections for human study subjects

Science Magazine Podcast

Science Podcast

News Commentary, News, Science

4.2 • 791 Ratings

🗓️ 9 May 2024

⏱️ 30 minutes

🔗️ Recording | iTunes | RSS

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Summary

Jupiter’s moon Io has likely been volcanically active since the start of the Solar System, and a proposal to safeguard healthy human subjects in clinical trials First on the show this week, a look at proposed protections for healthy human subjects, particularly in phase 1 clinical trials. Deputy News Editor Martin Enserink joins host Sarah Crespi to discuss the risks healthy participants face when involved in early testing of drugs for safety and tolerance. Then, we hear about a project to establish a set of global standards initiated by the Ethics Committee of France’s national biomedical research agency, INSERM. Next on this episode, a peek at the history of the most volcanically active body in the Solar System, Jupiter’s moon Io. Because the surface of Io is constantly being remodeled by its many volcanoes, it’s difficult to study its past by looking at craters or other landmarks. Katherine de Kleer, assistant professor of planetary science and astronomy at the California Institute of Technology, talks about using isotopic ratios in the moon’s atmosphere to estimate how long it’s been spewing matter into space. This week’s episode was produced with help from Podigy. About the Science Podcast Authors: Sarah Crespi; Martin Enserink Episode page: https://www.science.org/doi/10.1126/science.zyq2ig8 Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0	Introducing Peak Scientific. With over 25 years of expertise, Peak leads the industry in providing
0:06.7	reliable, high purity gas generators for LCMS and GCSMS. Whether you're in the lab conducting groundbreaking
0:13.7	research or pushing the boundaries of science, trust Peak Scientific to supply gas for undisrupted
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0:46.7	This is a science podcast for May 10th, 2024. I'm Sarah Crespi.
0:51.6	First on the show, an effort to safeguard healthy human subjects in clinical trials.
0:55.2	Deputy editor Martin Enshrink joins me to discuss the dangers these participants face, particularly in early trials that test drug safety. We talk about the new proposal
1:01.2	that offers protections for healthy subjects and a registry option. Next, we visit the most
1:06.5	volcanically active body in the solar system, Jupiter's Moon I.O. Researcher Catherine
1:11.8	DeClear talks about how her team analyze the moon's atmosphere to discover just how long its
1:17.2	volcanoes have been churning, burning, and spewing material into space. Before papers are published, a journal should be checking to make sure the work meets certain ethical standards when animals or human subjects are involved.
1:35.3	We have IRBs. These are institutional review boards that approve of research proposals before they're implemented, before people start participating.
1:43.2	But this doesn't cover all bases of potential harm to human subjects.
1:48.9	This week in science, Deputy News Editor Martin Encerich writes about a proposal for better
1:53.5	protections for people that appear to be falling through the cracks of this safety system.
1:58.9	Healthy human subjects involved in clinical trials. Hi, Martin. Welcome
2:02.8	back to the science podcast. Hey, Sarah. Hi. So this is kind of emphasizing healthy human
2:08.3	subjects and how they're treated in research. Is it a big difference between someone who has an
2:13.4	illness that wants to enroll in a trial and someone who is healthy? Yeah, there is a big difference.
2:19.5	I mean, when we talk about clinical trials, we talk a lot about what is called phase two and
	...

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