BS 211 Molecular Biologist Seth Grant

Brain Science with Ginger Campbell, MD: Neuroscience for Everyone

Ginger Campbell, MD

Life Sciences, Health & Fitness, Neuroscience, Medicine, Brain, Science

4.8 • 896 Ratings

🗓️ 25 August 2023

⏱️ 70 minutes

🔗️ Recording | iTunes | RSS

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Summary

This episode of Brain Science features the return of molecular biologist Seth Grant. We briefly review his decades of research into the complexity of the protein structure of the synapse and then we focus on his most recent paper, which describes how the life-span of synapse proteins appears to change as animals age. Grant reflects of the significance of this finding both for animal research and human medicine.

Papers discussed in this episode:

Bulovaite, E., Qiu, Z., Kratschke, M., Zgraj, A., Fricker, D. G., Tuck, E. J., Gokhale, R., Koniaris, B., Jami, S. A., Merino-Serrais, P., Husi, E., Mendive-Tapia, L., Vendrell, M., O'Dell, T. J., DeFelipe, J., Komiyama, N. H., Holtmaat, A., Fransén, E., & Grant, S. G. N. (2022). A brain atlas of synapse protein lifetime across the mouse lifespan. Neuron, 110(24), 4057–4073.e8. https://doi.org/10.1016/j.neuron.2022.09.009
Cizeron, M., Qiu, Z., Koniaris, B., Gokhale, R., Komiyama, N. H., Fransén, E., & Grant, S. G. N. (2020). A brainwide atlas of synapses across the mouse life span. Science (New York, N.Y.), 369(6501), 270–275. https://doi.org/10.1126/science.aba3163

Seth Grant has previously appeared on Brain Science several times including BSP 51, BSP 101, BS 137, BSP 150 and BS 176.

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Transcript

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0:00.0	Welcome to brain science, the
0:05.0	brain science, the podcast that explores how recent discoveries in
0:09.1	neuroscience are unraveling the mystery of how our brain makes us human. This is episode 211 and I'm your
0:17.0	host Dr. Ginger Campbell. Before I tell you about today's episode, I want to remind you that you can find complete show notes and episode
0:25.2	transcripts at brainscience podcast.com and you can send me email feedback at brain science
0:31.6	podcast at gmail.com. Today's episode features molecular
0:37.2	biologists Seth Grant for a record sixth time. Before we jump into today's interview I want to remind you that last
0:44.7	month's episode 210 was designed to help you get as much as possible out of
0:50.1	today's show so if you haven't had a chance to listen to episode 210, I encourage you to do so
0:55.7	after you enjoy this episode. I was first introduced to Seth Grant's work by a listener back in 2008.
1:04.8	And even though he has yet to write a book,
1:07.5	he's actually been on brain science more times
1:10.6	than any other guest.
1:12.3	Fortunately, Dr. Grant is an excellent science communicator.
1:16.8	But the main reason I keep having him on the show
1:19.1	is that his team and colleagues are continuing
1:21.2	to make surprising discoveries that could change how we understand
1:25.3	memory and behavior and more importantly could lead to more effective treatments for mental
1:30.1	illnesses like schizophrenia. Even though my understanding of molecular biology is very basic,
1:37.0	I appreciate the implications of his work and I am excited to share it with you.
1:41.0	But before I do, I need to mention a few items.
1:44.8	First, the Brainscience Mobile app is now called Brainscience Podcast. This update has
	...

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