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Carolina Reis Oliveira & Alessandra Zonari | OneSkin: Aging Myths, Senescent Cells, and How to Age Slower (#56)

The Kevin Rose Show

Kevin Rose

Science, Entrepreneurship, Longevity, Technology, Cryptocurrency, Kevin Rose, Health, Meditation, Business, Health & Fitness, Mindfulness, Society & Culture

4.92.1K Ratings

🗓️ 7 May 2024

⏱️ 73 minutes

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Summary

Are any of the so-called anti-aging products on the market actually effective? Kevin sits down with two experts, Carolina Reis Oliveira and Alessandra Zonari from OneSkin to get the latest on the complex process of aging, senescent cells aka “zombie cells”, types of collagen and how collagen production is affected, the #1 offender of skin, how sugar plays a role in aging and much more. This episode is packed with all you need to know to uncover the truth about skin aging and learn how to take care of your skin for a healthier and younger-looking appearance. Guest Bio and Links: Carolina Reis Oliveira is the Co-founder and CEO of OneSkin, a biotechnology company dedicated to developing solutions that extend skin health and, thereby, longevity. With a biochemistry degree and a Ph.D. in Stem Cell Biology and Tissue Engineering, Carolina has led her team to innovate in the realm of skincare by tackling aging at its source. Her work not only encompasses scientific research but also bridges the gap between science and consumer skincare products. Carolina is an alumnus of IndieBio, the world's largest seed biotech accelerator. She moved from Latin America to Silicon Valley in 2016 to found OneSkin and has been actively engaged in the longevity ecosystem in the Bay Area. Alessandra Zonari, co-founder of OneSkin, brings her expertise in immunology, stem cell biology, and bioinformatics to the forefront of the skincare industry. Her scientific acumen and dedication have been instrumental in the foundational research that led to the creation of OneSkin and its revolutionary products. Listeners can learn more about OneSkin at https://www.oneskin.co/ Partners: DeleteMe: 20% off removing your personal info from the web Plunge: Get $150 off the ultimate cold plunge ice bath Resources: Kevin's Newsletter: Join 100,000+ subscribers Scientific Publications: OneSkin Publications Show Notes: (0:00) Introduction (1:00) Get 20% off at kevinrose.com/deleteme (3:00) Get $150 off at kevinrose.com/plunge (4:40) Overview of today’s episode (8:00) Introduction to skin health (10:30) The science of skin aging and senescent cells (13:00) Fasting and autophagy benefits (19:30) Join Kevin’s newsletter (20:30) The role of sugar in aging (25:40) Collagen production and aging (29:00) How to spot an optimal vitamin C (36:30) Supplementation for skin (38:15) The start of OneSkin (46:40) Scientific ways to measure wrinkles (53:40) OS-01 FACE Topical Supplement (58:00) Probiotics and skin microbiome (58:30) Benefits of red light therapy (1:05:00) The latest on OneSkin (1:08:50) Common skincare myths Connect with Kevin: Website: https://www.kevinrose.com/ Instagram - @KevinRose X - @KevinRose YouTube - @KevinRose

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0:00.0

with this increase in awareness about well-being, eventually you needed to take care of your skin.

0:05.2

Obviously about how you look and how you feel, but also how your skin impacts your overall health.

0:11.5

When we start to see the things that I'm starting to see now in my 40s,

0:15.9

you know, little creases in the neck and around the eyes, like what's the degradation that's happening?

0:20.8

Basically what's happening is this accumulation of damage in our cells in the skin cells.

0:26.8

So they start reducing collagen for example.

0:29.4

And also what it's related is the accumulation of senescent cells also called

0:33.4

zombie cells and the inflammation that they secrete induces the cells around to

0:38.2

age faster. It's a very complex process that's happening on our body and a lot of it is influenced by lifestyle

0:46.4

choices. Sugar can bind to the proteins on their skin and can create advanced end glycan products.

0:54.5

The collagen that's on the skin

0:56.5

when it's bite into sugar, it gets more stiff

0:59.5

and can also cause.

1:01.2

What are some common skin care myths and misconceptions that you'd like to and I'm sure you are you're buying almost everything you buy online like 95% of the stuff I buy is now online

1:22.4

mostly big websites every 95% of the stuff I buy is now online.

1:23.3

Mostly big websites.

1:24.7

Every once a while, a smaller website,

1:26.7

but sure enough, at least once or twice a year,

1:30.0

my personal data gets leaked out there.

1:32.2

That means name, address, phone number,

1:34.4

it can be social, it could be date of birth,

1:35.8

it can be a whole slew of different things.

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