Hey all, welcome back to the Real Life Pharmacology podcast.

I'm your host, pharmacist Eric Christensen.

Thank you so much for listening today.

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All right. So the drug of the day today is Darifenison. Brand name of this medication is Ennablex.

This is an anticholinergic agent used in the management of

overactive bladder. Dosing of this medication is usually just once a day. It is an extended

release formulation, usually 7.5 milligrams once a day and then can be increased after a couple weeks if needed, up to 15 milligrams once a day.

Important to note it being extended release with the administration, it's definitely not recommended to crush or chew this dosage

form. So if it's too big or you've got a patient with swallowing difficulties, you better

recognize that we may need to switch to an alternative medication, alternative anticholinergic, if that's the class we're looking to use.

So something like Tolteridine, for example, or oxybutinin, those type of medications there.

Digging deeper a little bit into the mechanism of action, so how do anticholinergic agents help over active

bladder? Well, the specific receptor is the M3 receptor, also known as the muscarinic receptor. And what

Derophonisinin does is it's an antagonist or it blocks the M3 receptor,

and this prevents acetylcholine from binding to that receptor

and ultimately activating that receptor.

So this blocking or the prevention of acetycholine binding there,

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