Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Today’s sponsor is Freed AI! Freed’s AI medical scribe listens, transcribes, and writes notes for you. Over 15,000 healthcare professionals use Freed and you should too! Learn more here! Prednisone is a commonly used medication for its antiinflammatory and immunosuppressive action. On this episode I discuss prednisone pharmacology, ADRs, and much more. In the episode, I discuss how prednisone affects the HPA system in the body. Cortisol production can be greatly impacted by long term use of prednisone. GI adverse effects can be problematic with oral prednisone which is why we often give this medication with food or milk. Hyperglycemia is a complication from the use of prednisone. I've commonly seen blood sugar spike by 50-100+ mg/dL due to this medication. Osteoporosis is a long term risk with the use of prednisone. Prednisone can also impact the benefits of vaccination. I discuss this in greater depth in the drug interactions portion of the podcast.

Transcribed - Published: 24 April 2025

Today’s sponsor is Freed AI! Freed’s AI medical scribe listens, transcribes, and writes notes for you. Over 15,000 healthcare professionals use Freed and you should too! Learn more here! On this episode of the Real Life Pharmacology Podcast, I cover linagliptin pharmacology, adverse effects, drug interactions, and much more. Linagliptin is a DPP-4 inhibitor used to help control blood sugar levels in adults with type 2 diabetes. It works by increasing the levels of incretin hormones, which stimulate insulin release and decrease glucagon levels in the blood. Linagliptin is usually taken once daily and can be used alone or in combination with other diabetes medications. Unlike some other diabetes drugs, linagliptin does not usually cause weight gain or low blood sugar (hypoglycemia) when used alone. Linagliptin should not be used with GLP-1 agonists as it works on a similar pathway as that medication class.

Transcribed - Published: 17 April 2025

Meclizine is classified as a first-generation antihistamine. I discuss meclizine pharmacology, adverse effects, drug interactions, and much more. Meclizine is included on the Beers list due to its highly anticholinergic activity. Anticholinergic effects include constipation, dry eyes, dry mouth, urinary retention, and confusion. Sedation is an important adverse effect of meclizine. This adverse effect can be increased when used with other sedating medications such as opioids and benzodiazepines. Meclizine is primarily used for vertigo and motion sickness in clinical practice. The usual starting dose ranges between 12.5 to 25 mg. Meclizine is partially broken down by CYP2D6 so medications like bupropion can inhibit the breakdown of meclizine and lead to higher concentrations.

Transcribed - Published: 11 April 2025

In this episode, I discuss amphetamine/dextroamphetamine pharmacology, adverse effects, drug interactions, and much more. Stimulants like Adderall are well known to cause insomnia. This adverse effect can be affected by the timing of the dose. Lack of growth and poor appetite are two important things to monitor in pediatric patients taking Adderall. Changes in the pH of the stomach/gut can alter the absorption of Adderall. I discuss this in greater detail in this podcast episode. Cardiovascular monitoring is essential with the use of stimulants like Adderall. Pulse and heart rate are two important vital signs to assess.

Transcribed - Published: 3 April 2025

Today’s sponsor is Freed AI! Freed’s AI medical scribe listens, transcribes, and writes notes for you. Over 15,000 healthcare professionals use Freed and you should too! Learn more here! Benazepril is an ACE inhibitor used to treat hypertension by blocking the conversion of angiotensin I to angiotensin II, reducing vasoconstriction. Combining benazepril with potassium-sparing diuretics or potassium supplements increases the risk of hyperkalemia due to aldosterone suppression. Common side effects of benazepril include dry cough, hyperkalemia, and hypotension due to its effect on the renin-angiotensin-aldosterone system. Benazepril can be prescribed alone or in combination with other antihypertensive agents, such as diuretics or calcium channel blockers, to enhance blood pressure control. Benazepril has a long duration of action, allowing for once-daily dosing, which improves patient adherence and convenience in hypertension management.

Transcribed - Published: 27 March 2025

Today’s sponsor is Freed AI! Freed’s AI medical scribe listens, transcribes, and writes notes for you. Over 15,000 healthcare professionals use Freed and you should too! Learn more here! On this podcast episode, I cover loratadine pharmacology, adverse effects, drug interactions, and much more. Loratatdine is a second generation antihistamine. It has a lower incidence of central nervous system adverse effects compared to first-generation antihistamines like diphenhydramine. Loratadine dosing varies in pediatric patients and those with renal impairment. I get into the details on this podcast episode. Drug interactions aren't common with loratadine but I discuss a few that may be clinically significant.

Transcribed - Published: 20 March 2025

Modafinil (Provigil) is a CNS stimulant medication. I cover modafinil pharmacology, adverse effects, drug interactions, and much more on this podcast episode. You should be aware that modafinil is a Schedule 4 controlled substance so it does carry a risk of dependence and addiction. Modafinil can cause CYP3A4 induction and lead to lowering the concentrations of many medications. This includes antiepileptic agents and oral contraceptives. The most common adverse effects of modafinil include ramping up the body and causing symptoms such as anxiety and insomnia. Cardiovascular changes are a risk with modafinil as this medication can contribute to hypertension and tachycardia.

Transcribed - Published: 13 March 2025

This episode is sponsored by Meded101.com/store - Go check out their resources, books, and review courses! They will help you prepare to pass your pharmacology classes and board exams! Lansoprazole is a PPI that can be used for GERD, ulcers, and other GI conditions. B12 and magnesium deficiency are possible long-term mineral and vitamin effects. Augmentin is a combination medication of amoxicillin and clavulanate. It is an antibiotic for infection. Diarrhea is the most common adverse effect. Lovastatin is a cholesterol-lowering medication. It is often not a preferred statin due to CYP3A4 interaction and it is less potent than other medications. Valacyclovir is a prodrug that gets converted to acyclovir. It is an antiviral medication and can treat herpes zoster and herpes simplex infections. Chlorpromazine is a dopamine antagonist that has anticholinergic activity as well. It is a first-generation antipsychotic medication.

Transcribed - Published: 6 March 2025

Today’s sponsor is Freed AI! Freed’s AI medical scribe listens, transcribes, and writes notes for you. Over 15,000 healthcare professionals use Freed and you should too! Learn more here! Clopidogrel (Plavix) is an antiplatelet medication. You need to understand the pharmacokinetics of clopidogrel and how CYP2C19 affects this medication. Doxycycline is a tetracycline antibiotic. Calcium, iron, and other metal cations can bind doxycycline and reduce the absorption of the medication. Hyzaar is a combination of losartan and hydrochlorothiazide. Losartan is an ARB and hydrochlorothiazide is a thiazide diuretic. Kytril (granisetron) is an antiemetic medication. It is from the same class of medication as the more commonly used ondansetron. Restoril (temazepam) is a benzodiazepine. It is primarily used to treat insomnia as it has a much shorter half-life than many of the other benzodiazepines.

Transcribed - Published: 27 February 2025

Today’s sponsor is Freed AI! Freed’s AI medical scribe listens, transcribes, and writes notes for you. Over 15,000 healthcare professionals use Freed and you should too! Learn more here! On this episode of the Real Life Pharmacology Podcast, we will cover medications 186-190 on the Top 200 Drugs List. The medications included in the podcast episode are Sonata, Zebata, Zovirax, Coumadin, and Luvox. Sonata (ezopiclone) is a Z-drug used for insomnia. It has many similar effects to benzodiazepines and a similar mechanism of action. Zebeta (bisoprolol) is a beta-blocker used for the treatment of hypertension, atrial fibrillation, and heart failure amongst other indication. Zovirax (acyclovir) is an antiviral medication used to treat various viral infection. It needs to be dosed numerous times throughout the day which is a downside to use. Coumadin (warfarin) is an anticoagulant. It is most well known for its need to have INRs drawn to assess drug levels. Luvox (fluvoxamine) is an SSRI antidepressant. It is well known for its ability to cause drug interaction and is often not a first line agent because of this reason.

Transcribed - Published: 20 February 2025

On this Real Life Pharmacology Podcast episode, we cover medications 181-185. Proscar is the brand name for finasteride. This medication can be helpful in shrinking the size of the prostate but it does typically take a while to work (months). Sinemet is a combination of carbidopa and levodopa. Levodopa is converted in the central nervous system to dopamine to help alleviate a shortage of dopamine in the brain. Risedronate is a bisphosphonate medication that can be used in the treatment of osteoporosis. Albuterol (Ventolin) is a short-acting beta-agonist that is used to relieve symptoms of acute respiratory distress most often associated with an asthma exacerbation. Tramadol is classified as an opioid analgesic. It also has activity similar to SNRIs as it has the ability to increase serotonin and norepinephrine in the brain.

Transcribed - Published: 13 February 2025

Prednisolone is a corticosteroid that is often used in pediatrics. Hyperglycemia, insomnia, and GI upset are relatively common adverse effects. Ibuprofen is a commonly used OTC pain reliever. It is classified as an NSAID and can increase GI bleed risk and exacerbate heart failure. Aceon is the brand name for perindopril. ACE inhibitors are well known to cause drug induced cough and will cause hyperkalemia. Trazodone is classified as an antidepressant but is frequently used to treat insomnia because of its sedative properties. Pioglitazone is an oral anti-diabetes medication that should be avoided in patients with heart failure.

Transcribed - Published: 6 February 2025

Today’s sponsor is Freed AI! Freed’s AI medical scribe listens, transcribes, and writes notes for you. Over 15,000 healthcare professionals use Freed and you should too! Learn more here! On this episode of the Top 200 drugs podcast, we are going to cover these 5 medications: Cyclosporine, insulin glargine, tadalafil, amitriptyline, and gemfibrozil. Cyclosporine is a calcineurin inhibitor that suppresses the immune system. This is useful in patients who have had an organ transplant. Insulin glargine is a long-acting insulin product that can be used in type 1 and type 2 diabetes. I discuss adverse effects, dosing, and much more. Tadalafil is a PDE-5 inhibitor that can be used to treat sexual dysfunction. The nitrate drug interaction is one of the most highly tested drug interactions in school. Amitriptyline is a TCA. It is highly anticholinergic and because of this is not a great medication to utilize in elderly patients. Gemfibrozil is primarily used to lower triglyceride levels. This medication can significantly increase the risk for rhabdomyolysis in patients taking statin medications.

Transcribed - Published: 30 January 2025

Today’s sponsor is Freed AI! Freed’s AI medical scribe listens, transcribes, and writes notes for you. Over 15,000 healthcare professionals use Freed and you should too! Learn more here! On this episode of the Top 200 Drugs podcast from Real Life Pharmacology, we cover Percocet, Epogen, quetiapine, glimepiride, and tirzepatide. These are drugs 166-170. Percocet is a combination analgesic. It contains acetaminophen and oxycodone. Pay attention to acetaminophen intake from all sources when patients are on this medication. Epogen (epoetin alfa) stimulates the production of red blood cells. This medication can be useful in treating anemia. Quetiapine (Seroquel) is an antipsychotic. It is often used in patients with hallucinations and delusions associated with Parkinson's disease because it has a lower potential to block dopamine receptors compared to other antipsychotics. Glimepiride is a sulfonylurea. This medication stimulates the release of insulin which can help lower blood sugars in diabetes. Tirzepatide (Mounjaro) is a combination GIP and GLP-1 receptor agonist that can be used for weight loss and the treatment of diabetes.

Transcribed - Published: 23 January 2025

On this podcast episode of the top 200 drugs, I'm covering liraglutide, folic acid, clotrimazole, empagliflozin, and semaglutide. Liraglutide is a GLP-1 agonist that can be used for weight loss as well as diabetes. The most common adverse effect of this medication is nausea. Folic acid is a commonly used supplement in pregnancy as well as in those patients taking methotrexate. Deficiency of folic acid can lead to anemia. Clotrimazole is an antifungal agent. It is mostly used for topical purposes such as athlete's foot and vaginal yeast infections. Empagliflozin was originally developed as a diabetes medication but can be helpful in patients with heart failure and CKD. I discuss this in greater detail in the podcast. Semaglutide is another GLP-1 agonist that is used for diabetes care as well as weight loss. The formulation used for diabetes is Ozempic while the weight loss product is Wegovy.

Transcribed - Published: 16 January 2025

Welcome back to the Real Life Pharmacology podcast! We are on the home stretch of the top 200 medications. This is meant to be a quicker refresher of some of the most important drugs you'll come across in practice. Please be sure to go search the archives at RealLifePharmacology.com if you are looking for more information on one specific medication. We have over 300 individual episodes on specific drugs! On this episode of the Top 200 medications, we've covered the medications below. Niaspan (niacin) is vitamin B3 and may be used in patients who fail other therapies for triglyceride management. Uroxatral (alfuzosin) is a selective alpha-blocker that can be helpful in relieving urinary retention symptoms in BPH. Biaxin (clarithromycin) is a macrolide antibiotic that is notorious for many drug interactions because it inhibits CYP3A4. Zomig (zolmitriptan) is a "triptan" medication that can be used for the acute relief of migraine headaches. Invokana (canagliflozin) was one of the first SGLT2 inhibitors invented that can be used to lower blood sugar in type 2 diabetes.

Transcribed - Published: 9 January 2025

Today’s sponsor is Freed AI! Freed’s AI medical scribe listens, transcribes, and writes notes for you. Over 15,000 healthcare professionals use Freed and you should too! Learn more here! On this episode of the Top 200 Drugs Podcast, I cover medications 151-155. This podcast includes; cefuroxime, ketoconazole, pregabalin, esomeprazole, and ipratropium/albuterol. Cefuroxime is a 2nd generation cephalosporin that has a very similar bacterial coverage profile to amoxicillin. It has significant gram positive coverage. Ketoconazole is an azole antifungal medication. It is well known for causing hepatotoxicity as well as interactions via CYP3A4. Pregabalin has a lot of similarities with gabapentin. It can be used fo various pain syndromes such as neuropathy and fibromyalgia. Esomeprazole is a PPI and has a similar profile to omeprazole. It inhibits CYP2C19 and has a few notable interactions that I cover in this episode. Ipratropium and albuterol is a combination of a short acting anticholinergic and short acting beta agonist.

Transcribed - Published: 2 January 2025

Today's sponsor is Freed AI! Freed’s AI medical scribe listens, transcribes, and writes notes for you. Over 15,000 healthcare professionals use Freed and you should too! Learn more here! On this episode of the Top 200 Drugs Podcast, I cover medications 146-150. This podcast includes; sevelamer, dalteparin, sertraline, clonazepam, and irbesartan. Sevelamer is a phosphate binder that is used to treat hyperphosphatemia in patients with chronic kidney disease. Dalteparin is a low molecular weight heparin product that is used to prevent and treat blood clots. Sertraline is a commonly used SSRI that can be helpful in managing depression and anxiety. Clonazepam is a benzodiazepine that can be used for acute relief of anxiety. Sedation, confusion, and fall risk are potential adverse effects. Irbesartan is an ARB that can be used for hypertension. Hyperkalemia and angioedema are two adverse effects to be aware of.

Transcribed - Published: 26 December 2024

On this top 200 drugs podcast, we are covering medications 141-145. Raltegravir, ustekinumab, meloxicam, infliximab, and Nighttime Cold and Flu are the medications that are covered on this episode. Raltegravir is an integrase inhibitor that is used to manage HIV infection and may also be used for post-exposure prophylaxis. Ustekinumab is a monoclonal antibody that can help reduce inflammation by binding interleukins. Meloxicam is an NSAID used for pain and anti-inflammatory purposes. GI bleeding risk is a top adverse effect to monitor for. Infliximab is a monoclonal antibody that can be used for autoimmune disorders such as psoriatic arthritis, rheumatoid arthritis, ulcerative colitis, and Crohn's disease. Nighttime Cold and Flu medication is a combination product that often includes acetaminophen, dextromethorphan, and doxylamine.

Transcribed - Published: 19 December 2024

On this episode, I cover cinacalcet, solifenacin, haloperidol, hydrocortisone (focused on topical), and insulin NPH. Cinacalcet is a calcimimetic medication that can be helpful in hyperparathyroidism and useful for managing hypercalcemia. Solifenacin is a urinary antimuscarinic used primarily for overactive bladder. It is an anticholinergic medication that can be problematic in our geriatric patients. Haloperidol is a first generation antipsychotic that has a high incidence of EPS relative to many newer antipsychotics. Hydrocotorisone is one of the most common topical corticosteroids that can be used to reduce inflammation and redness from skin reactions. Insulin NPH is an intermediate acting insulin that is meant to be given on a routine basis. It has fallen out of favor since insulin glargine and other long acting agents allow for few injections and more stable kinetics.

Transcribed - Published: 12 December 2024

On this episode of the Top 200 drugs podcast from Real Life Pharmacology, I cover medications 131-135 which include enoxaparin, methylphenidate, rosuvastatin, denosumab, and dabigatran. Enoxaparin is an injectable anticoagulant that can cause heparin-induced thrombocytopenia. Methylphenidate is a stimulant medication that can be used to treat ADHD. Cardiovascular adverse effects are possible. Rosuvastatin inhibits HMG-CoA Reductase which helps lower LDL in the management of hypercholesterolemia. Denosumab is a monoclonal antibody that is indicated for osteoporosis and may cause hypocalcemia. Dabigatran was one of the first direct oral anticoagulants to be produced. It is dosed twice daily and has warnings about use in patients over the age of 75.

Transcribed - Published: 5 December 2024

In this episode of the Top 200 Drugs Podcast, we cover medications 126-130. Trastuzumab is a monoclonal antibody that can be used for breast cancer that expresses the HER2 protein. Atripla is an HIV medication that contains three separate medications that are beneficial in reducing viral load. Rivaroxaban is an anticoagulant that may be commonly used in the management of stroke and deep vein thrombosis. Fioricet is a combination of three medications. Butalbital, acetaminophen, and caffeine are the three ingredients in this medication. Insulin detemir is a long-acting insulin analog that lowers blood sugar. This medication is used to target fasting blood sugars.

Transcribed - Published: 28 November 2024

On the top 200 drugs podcast, we cover 5 more medications. The medications covered on today's episode include; omalizumab, nitroglycerin, apixaban, gabapentin, and etanercept. Omalizumab is a monoclonal antibody used in moderate to severe asthma. It targets IgE-mediated asthma attacks and reactions. Anaphylaxis is a significant concern with the use of this medication. Sublingual nitroglycerin is frequently used on an as needed basis for angina symptoms. I discuss major drug interactions and much more. Apixaban is an anticoagulant used to prevent stroke in atrial fibrillation. It can also be used in DVT/PE treatment and prevention. Gabapentin is classified as an antiepileptic agent but is most commonly used for neuropathic type pain. Etanercept targets TNF alpha which plays an important role in autoimmune diseases such as rheumatoid arthritis.

Transcribed - Published: 21 November 2024

In this episode of the Top 200 Drugs Podcast, I cover glyburide, citalopram, olmesratan, carvedilol, and tiotropium. Glyburide is a sulfonylurea that is well known to cause hypoglycemia and weight gain because it stimulates the pancreas to increase insulin release. Citalopram is an SSRI most well known for its potential to increase the risk for QTc prolongation. It has a notorious drug interaction with omeprazole Olmesartan is an ARB that can be used for hypertension. Hyperkalemia is an electrolyte imbalance that can be caused by its use. Carvedilol is one of the few beta-blockers with significant alpha-blocking and beta-blocking activity. I discuss what this means in this Top 200 drugs podcast. Tiotropium is an anticholinergic medication that can open the airway. It is most commonly used for COPD.

Transcribed - Published: 14 November 2024

Clindamycin is an antibiotic for infection. It inhibits protein synthesis by binding to the 50s ribosomal subunit and is well known to contribute to C. Diff. risk. Acetaminophen is a common over-the-counter medication that relieves pain and fever. It does not have much benefit in reducing inflammation, however. Ferrous sulfate is a supplement that can be useful in treating anemia. Dark stools and constipation are two common adverse effects. Eletriptan is a medication used to abort migraine headaches. It has serotonin action. I discuss the potential for interactions with other serotonergic medications. Methocarbamol is an older skeletal muscle relaxant that makes an appearance on the Beers list as it can cause sedation, confusion, and increase the risk of falls.

Transcribed - Published: 7 November 2024

Zoledronic acid is a bisphosphonate that can be used to manage hypercalcemia of malignancy and osteoporosis. Glipizide is an anti-diabetes agent that is classified as a sulfonylurea. Weight gain and hypoglycemia and two big concerns with this agent. Lactulose is classified as a laxative but is more commonly used to reduce ammonia levels in hepatic encephalopathy. Rabeprazole is a PPI used to reduce gastric acid secretions and improve conditions such as GERD, peptic ulcer disease, and Barrett's esophagus. Methotrexate is classically grouped with oncology agents but is frequently used in autoimmune conditions like rheumatoid arthritis and Crohn's disease.

Transcribed - Published: 31 October 2024

On this episode of the Real Life Pharmacology podcast, we cover medications 101-105 of the top 200 drugs Atomoxetine is a norepinephrine reuptake inhibitor that is used in the management of attention deficit hyperactivity disorder. Zolpidem is a medication that is used for insomnia. It has a very similar adverse effect profile to benzodiazepines. Advair is a commonly used respiratory medication for asthma. It is a combination of a long-acting beta agonist and inhaled corticosteroid. Levofloxacin is a quinolone antibiotic that has a boxed warning for neuropathy, tendon rupture, and CNS adverse effects. Imipramine is a tricyclic antidepressant that is highly anticholinergic. Dry eyes, dry mouth, constipation, urinary retention, sedation, and memory impairment are potential adverse effects.

Transcribed - Published: 24 October 2024

We have finally reached 100 of the top 200 drugs podcasts! On this episode, we tackle methadone. This is a complex opioid used for opioid use disorder and may also be used for pain. Enalapril is an ACE inhibitor that is used for hypertension. Cough and hyperkalemia are two major adverse effects to remember. Oseltamivir is a neuraminidase inhibitor. In patients with poor renal function, we need to make sure to adjust the dose accordingly. Ropinirole is a dopamine agonist. This medication is primarily used for restless leg syndrome but is also indicated for Parkinson's disease. Penicillin VK is the original penicillin antibiotic. Common indications of this medication are strep throat, skin and soft tissue infections, and syphilis.

Transcribed - Published: 17 October 2024

On this episode of the Real Life Pharmacology Podcast, I cover 5 more medications of the top 200. Fenofibrate is a medication used primarily to reduce triglycerides. This medication differs from statins which tend to focus on LDL management. Doxazosin is an alpha-blocker. The primary indications of doxazosin are hypertension and BPH. Naproxen is an NSAID. Of all the NSAIDs, naproxen is one of the lower-risk agents with regard to cardiovascular risk. Spironolactone is an aldosterone antagonist and also classified as a potassium sparing diuretic. Memantine is an NMDA antagonist that is indicated for the management of Alzheimer's dementia. If you are looking for study materials and our list of popular Amazon books, check out meded101.com/store!

Transcribed - Published: 10 October 2024

On this episode of the Real Life Pharmacology podcast, we cover 5 more medications in the top 200. Metronidazole is an antibiotic for infection. One of the most common complaints from patients involves reporting of a metallic taste in the mouth. Levetiracetam is an anti-seizure medication. Sedation, dizziness, and other adverse effects of the central nervous system are the most common complications. Colchicine is a gout medication. The most memorable side effect associated with this medication is diarrhea. Olanzapine is an antipsychotic. Olanzapine carries a higher risk for metabolic syndrome compared to other antipsychotics. Dutasteride is a 5 alpha-reductase inhibitor that is indicated for the treatment of BPH. If you are looking for all of our study materials and Amazon books, check them out at Meded101.com/store!

Transcribed - Published: 3 October 2024

On this episode of the Real Life Pharmacology podcast, I cover medications 81 through 85 on the top 200 drug list. Famotidine is an H2 blocker. H2 blockers are less potent than PPIs but can be used to manage heartburn symptoms. Aspirin is technically an NSAID but is primarily used for cardioprophylaxis purposes. Senna is a stimulant laxative. I often see this medication used with opioids to help manage opioid-induced constipation. Novolog is a rapid acting insulin used to bring down post prandial blood sugars. I discuss sliding scale insulin and other concepts with this medication. Baclofen is a skeletal muscle relaxant. It has central nervous system depressant effects which can be especially problematic in elderly patients. Support the sponsor Meded101.com by going to meded101.com/store - Study materials, books, review courses for pharmacists, pharmacy students, pharmacy technicians, nurses, physicians, prescribers, dietitians, and all others who want to learn pharmacology!

Transcribed - Published: 26 September 2024

Reglan (metoclopramide) is used for gastroparesis and inhibits gastric smooth muscle by blocking dopamine receptors. Relafen (nabumetone) is a non-selective inhibition of COX-1/COX-2 which leads to a reduction of inflammation via reduced prostaglandins. Keflex (cephalexin) is a 1st generation oral cephalosporin that covers common gram positive organisms like Staph and Strep species. Effexor (Venlafaxine) is an SNRI and inhibits both serotonin and norepinephrine reuptake. Primary uses include anxiety and depression. Boniva (ibandronate) inhibits osteoclasts which helps treat osteoporosis. Osteoclasts break down bone to help pull calcium into the bloodstream.

Transcribed - Published: 19 September 2024

This episode is sponsored by Freed – Freed is an amazing time saver for busy healthcare professionals! It listens, transcribes, and writes medical notes for you! Go check them out and support our sponsor! Robitussin (Guaifenesin) is a medication that is used as a cough suppressant. It is often combined with numerous other medications so patients need to pay attention Valium (diazepam) is a benzodiazepine used to treat anxiety or seizures. Falls, dizziness, confusion, and sedation are common adverse effects. Viagra (sildenafil) makes the list at number 73. This medication is a PDE-5 inhibitor that can be used for erectile dysfunction. Bactroban (mupirocin) is a topical antibiotic that can be used for superficial skin infections. Januvia (Sitagliptin) is a DPP4 inhibitor used for treating hyperglycemia in type 2 diabetes. It doesn't reduce A1C quite as much as other diabetes medications like SGLT2 inhibitors and GLP-1 agonists.

Transcribed - Published: 12 September 2024

This episode is sponsored by Freed – Freed is an amazing time saver for busy healthcare professionals! It listens, transcribes, and writes medical notes for you! Go check them out and support our sponsor! Pantoprazole (Protonix) is a PPI that can be used for GERD and peptic ulcer disease. I differentiate why this medication is different from the commonly used omeprazole. Dicyclomine (Bentyl) is an anticholinergic medication that may be used to help reduce pain and spasms associated with irritable bowel syndrome. Sumatriptan (Imitrex) is a selective 5HT1 receptor agonist, which potentially helps with vasoconstriction that contributes to migraine symptoms. Chlorhexidine (Peridex) is an antibiotic oral rinse that can be used for gingivitis. Metoprolol (Lopressor, Toprol XL) is a beta-blocker that may be used for atrial fibrillation, angina prevention, and hypertension. It is not a first-line medication for hypertension.

Transcribed - Published: 5 September 2024

This episode is sponsored by Freed - Freed is an amazing time saver for busy healthcare professionals! It listens, transcribes, and writes medical notes for you! Go check them out and support our sponsor! In this episode, we highlight some of the most important clinical pearls (and highly testable pearls) on the following medications; Suboxone, lisdexamfetamine, nortriptyline, insulin lispro, and valproic acid. Suboxone is a combination of buprenorphine and naloxone used for opioid use disorder. Lisdexamfetamine is a stimulant medication that can be used to manage ADHD. Common side effects include weight loss, insomnia, hypertension, and tachycardia. Nortriptyline is a TCA medication known for its ability to cause anticholinergic side effects like constipation, dry eyes, dry mouth, urinary retention, and confusion. Insulin lispro is a rapid-acting insulin medication that is most often used to bring down post-prandial blood sugar. Valproic acid is an antiepileptic medication that can also be used for migraines.

Transcribed - Published: 29 August 2024

This episode is sponsored by Freed - Freed is an amazing time saver for busy healthcare professionals! It listens, transcribes, and writes medical notes for you! Go check them out and support our sponsor! In this episode, we highlight some of the most important clinical pearls on the following medications; nitrofurantoin, fentanyl patches, isosorbide mononitrate, fluoxetine, and triamcinolone. Nitrofurantoin is an antibiotic used for UTIs. We need to be careful with this medication in patients with CKD. Fentanyl is an opioid. There are many clinical quirks with fentanyl patches. For a full rundown, check out this previous podcast episode. Isosorbide mononitrate is a nitrate medication so we need to be careful with the use of PDE-5 inhibitors. Fluoxetine is an SSRI. It has a longer half-life than most SSRIs. I discuss what that means in this episode. Triamcinolone (topical) is most frequently used for redness, itching, and skin irritation.

Transcribed - Published: 22 August 2024

On this episode of the Real Life Pharmacology podcast, I cover medications 51-55. They are eszopiclone, celecoxib, estrogen, moxifloxacin, and donepezil. Eszopiclone is a "Z" drug used for insomnia. Its adverse effect profile is very similar to benzodiazepines. Celecoxib is a COX-2 Inhibitor used for pain and inflammation. I discuss how this medication differs from traditional NSAIDs. Estrogen therapy is used for menopausal symptoms but carries a risk of cancer and blood clots. Moxifloxacin is a quinolone antibiotic. Binding drug interactions, boxed warnings, and QTc prolongation are potential concerns. Donepezil is a medication used for dementia. I discuss its mechanism of action and common adverse effects.

Transcribed - Published: 15 August 2024

On this episode, we continue with the Top 200 Drugs podcast. We cover the basics of the following drugs: tizanidine, risperidone, ramipril, pravastatin, and terazosin. Tizanidine is a skeletal muscle relaxant that has drug interactions via CYP2D6 Risperidone is a 2nd generation antipsychotic. Be on the lookout for EPS, hyperprolactinemia, sedation, and metabolic syndrome. Ramipril is an antihypertensive agent that is an ACE Inhibitor. Cough and hyperkalemia are two important adverse effects. Pravastatin is an HMG-CoA reductase inhibitor that lowers LDL levels. It isn't as potent as other statins and I discuss this on the podcast episode. Terazosin is a non-selective alpha-blocker that may be used for BPH and hypertension.

Transcribed - Published: 8 August 2024

On this episode of the Real Life Pharmacology podcast, I continue my education on the top 200 drugs. Raloxifene, prednisone, phenytoin, fish oil, and ezetimibe are covered in this podcast episode. Prednisone is a corticosteroid that may cause hyperglycemia, insomnia, GI upset, osteoporosis, HPA suppression, and hypertension as primary adverse effects. Raloxifene is classified as a SERM and can be used for osteoporosis and breast cancer. DVT and hot flashes are significant adverse effect concerns. Fish oil (Lovaza) is used to reduce triglycerides. Elevated triglycerides can increase the risk of pancreatitis. Ezetimibe inhibits the absorption of cholesterol through the gut. It lowers LDL but not to the extent of statins. Phenytoin is a narrow therapeutic index medication (NTI) that is used as an anticonvulsant. Ataxia, confusion, GI upset, and vertical nystagmus are potential signs of toxicity.

Transcribed - Published: 1 August 2024

On this episode of the Real Life Pharmacology podcast, I continue my coverage with the Top 200 Drugs Podcast. Here's the list of medications we will cover. Lorazepam (Ativan) is a benzodiazepine well known for its anxiolytic and anti-seizure properties. Phenazopyridine (Pyridium) is a urinary analgesic that can change the color of the urine to a reddish/orange color as one of its adverse effects. Hydroxychloroquine (Plaquenil) is a DMARD used in rheumatoid arthritis and Lupus. One highly testable and unique nugget to remember is that it can cause retinopathy. Lidocaine patch (Lidoderm) is used topically to help with various types of pain including neuropathy and postherpetic neuralgia. Diclofenac (Cataflam) is an NSAID used as an analgesic and anti-inflammatory. It can increase the risk of GI bleed, edema, renal failure, and thrombosis.

Transcribed - Published: 25 July 2024

On this episode of the Real Life Pharmacology podcast, I discuss drugs 31-35 of the top 200 drugs. Ethinyl estradiol/drospirenone is a combined oral contraceptive used for birth control purposes. Hydralazine is a direct vasodilatory that can be used for hypertension and heart failure. Benztropine is an older anticholinergic medication originally indicated for Parkinson's disease but most commonly used to manage EPS symptoms from dopamine-blocking agents such as antipsychotics. Tussionex is a combination medication of chlorpheniramine and hydrocodone. It is used to help alleviate cough. Paroxetine is an SSRI used for the treatment of depression, anxiety, and other psychiatric disorders.

Transcribed - Published: 18 July 2024

On this episode of the Top 200 Drugs pharmacology podcast, I cover fluticasone nasal spray, allopurinol, alendronate, famotidine, and cefdinir. Fluticasone is a corticosteroid that can be used nasally for the treatment of allergic rhinitis. Allopurinol is a xanthine oxidase inhibitor used to reduce uric acid and prevent gout flares. Alendronate is a bisphosphonate that inhibits the action of osteoclasts. This action helps treat osteoporosis. Famotidine is a histamine-2 receptor antagonist that helps reduce gastric acid secretion and alleviate heartburn symptoms. Cefdinir is a third-generation cephalosporin that is often used as an alternative for those who cannot take penicillin antibiotics. There is a small risk for cross-reactivity that a clinician has to consider.

Transcribed - Published: 11 July 2024

Lamotrigine is an antiseizure medication and also may be used for bipolar disorder. A rash is a major side effect to remember with this medication. Valganciclovir is an antiviral medication that can be used to prevent cytomegalovirus (CMV) in patients with a suppressed immune system. Fluconazole is an azole antifungal that can be used to treat candidiasis, blastomycosis, and tinea infections. Drug interactions, QTc prolongation, and hepatotoxicity are potential risks. Atenolol is a beta-blocker used to treat atrial fibrillation and hypertension. It is relatively selective for beta-1 receptors meaning that it doesn't affect the lungs as much as non-selective agents. Montelukast is a medication that blocks the actions of leukotrienes. This can be beneficial for the management of allergies and asthma.

Transcribed - Published: 4 July 2024

In this episode of the Real Life Pharmacology podcast, I cover drugs 16-20 of the top 200 drugs. This podcast includes information about clozapine, furosemide, heparin, tetracycline, and vardenafil. Clozapine has five boxed warnings and these are all items that you may see on your pharmacology and board exams! I've also blogged about these in the past at meded101. Furosemide is a loop diuretic and a common indicator of the prescribing cascade. I discuss this in this podcast episode. Heparin can cause thrombocytopenia. I discuss what HIT (heparin-induced thrombocytopenia) may look like.

Transcribed - Published: 27 June 2024

Metformin is a medication used in the management of diabetes. It can cause significant diarrhea, B12 deficiency, and in rare cases, lactic acidosis. Atorvastatin (Lipitor) is a statin medication used for cholesterol management. It lowers LDL and is associated with myopathy. Omeprazole is a PPI used for GERD and has drug interactions with citalopram and clopidogrel. Ciprofloxacin is a quinolone antibiotic used to treat gram-negative infections and UTIs. It carries numerous risks such as tendon rupture. Ondansetron is an antiemetic medication used in the management of nausea and vomiting. I discuss the prescribing cascade in relation to this medication.

Transcribed - Published: 20 June 2024

On this episode of the Real Life Pharmacology podcast, I discuss drugs 6-10 of the top 200 drugs. Included in this podcast episode are two antibiotics that are frequently used in pediatrics. Those two antibiotics are azithromycin and amoxicillin. Alprazolam is a benzodiazepine. It is a controlled substance that is used for the acute relief of anxiety. It is not well tolerated in the elderly. Hydrochlorothiaizde is a thiazide diuretic used primarily for hypertension. It can exacerbate gout and cause frequent urination. Amlodipine is a dihydropyridine calcium channel blocker. The most important adverse effect to remember with this medication is edema.

Transcribed - Published: 13 June 2024

On this episode of the Real Life Pharmacology Podcast, I start my journey on summarizing the most highly testable pearls with the top 200 medications. I'm going through the top 200 medications, 5 drugs at a time, and sharing my experience and clinically relevant information about these medications. Escitalopram is an SSRI that can cause serotonin syndrome, sexual dysfunction, and SIADH. Simvastatin is a cholesterol medication that can cause myopathy and rhabdomyolysis. Levothyroxine is a thyroid hormone replacement medication that has numerous binding drug interactions. Vicodin is a brand name combination of hydrocodone and acetaminophen. It is an opioid combined with and OTC analgesic. Lisinopril is an ACE inhibitor used for hypertension that can cause a chronic dry cough and hyperkalemia.

Transcribed - Published: 6 June 2024

On this episode, I discuss timolol pharmacology, adverse effects, drug interactions, and much more. Timolol is a non-selective beta-blocker so it blocks both beta-1 and beta-2 receptors. Since timolol blocks beta-2 receptors, it can blunt the effect of respiratory medications that have beta-agonist action. Beta-blockers are notorious for causing bradycardia and pulse is an important monitoring parameter for timolol.

Transcribed - Published: 30 May 2024

Continuous Glucose Monitors (CGMs) are becoming an important tool in the management of diabetes. I break down some of the most common clinical practice pearls you should know.

Transcribed - Published: 23 May 2024

On this episode of the Real Life Pharmacology Podcast, I cover some of the most common food and supplement drug interactions. The 3 G's can potentially increase the risk of bleeding in patients on anticoagulants and antiplatelets. I discuss what supplements these are. There are some vitamins that can cause drug interactions. Vitamin C is a supplement that can alter the absorption of some medications. Metal cations like iron can bind certain medications and reduce absorption. I discuss which medications are most likely to be affected.

Transcribed - Published: 16 May 2024