4.9 • 806 Ratings
🗓️ 1 July 2020
⏱️ 5 minutes
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0:00.0 | So, guys, Derek, moreplace, more dates.com. |
0:01.8 | Today we're going to be talking about do men become more sensitive to D.HT as they age despite |
0:07.4 | having lower androgen levels? |
0:08.8 | So there's this common misconception that men produce more DHT as they get older. |
0:15.1 | And that's why, you know, you have more hair loss in old age rather than in your youth. |
0:20.0 | And I sort of already touched on that in my previous |
0:21.8 | video where you don't produce more DHD as you get older. It's actually not the case whatsoever. |
0:27.7 | But then the theory arises is do you become more sensitive to the DHD you do produce or do your |
0:33.5 | androgen receptors upregulate to kind of pick up the slack for the deficit of |
0:39.1 | androgenic activity occurring because you're just producing less testosterone and as a result |
0:44.0 | of less testosterone you're producing less dhc too so do you produce do your androgen receptors |
0:49.3 | upregulate as you age to kind of like fill the void so in regards to testosterone dhc levels it's still |
0:56.0 | unknown whether the requirements of elderly men are identical to the requirements of young men |
1:02.3 | for like physiologic functions and whatnot so there's some evidence to suggest that there is |
1:08.3 | increased sensitivity to androgens in elderly males. |
1:10.9 | So, for example, at the level of the feedback system, some studies, not all of them, |
1:15.2 | but some show a decrease in androgen receptor concentration in tissues of elderly men and elderly |
1:21.5 | animals suggesting a saturation of the receptor sites at a lower testosterone concentration and a decrease of the |
1:29.7 | maximal genomic effect of testosterone. Also changes in the CAG repeat length of the AR gene |
1:36.9 | may be involved in age-related decline of plasma testosterone levels. The latter appears to decline |
1:43.2 | more rapidly in subjects with a lower number |
1:46.0 | of CAG repeats. And this is kind of like terminology that you don't really need to know about, |
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