Dht is in bioassays equivalent to 2.5 to 10 fold more potent than testosterone at the

androgen receptor.

It's so androgenic that even though it is present at least systemically, obviously tissue

specific is different, like overall concentrations of it in the body are a fraction of that

of testosterone.

It is still the primary hormone responsible for the development of

secondary sex characteristics like deepening of the voice development of facial hair body hair

growth of the penis and scrotum or it's at least significantly implicated in reaching full maturity

perhaps is a more accurate statement so during during puberty, men with deficiency in

this enzyme do not develop much facial hair, body hair, notably no endogenic alopecia. And this is

kind of the inception of some of these hair loss prevention drugs, which operate via this enzyme pathway.

But anyways, and they also have a small prostate. males with 5 a r deficiency are actually raised as

female until they hit puberty because they didn't have enough dhc to markedly differentiate themselves

as males pre puberty so they were born appear to be female and then you know when they hit

puberty all of a sudden the spike in testosterone makes it a bit more obvious that things are not like classically female.

Once they hit puberty and test level spike, the penis and other androgen supported structures start to enlarge.

And but still, without the DHD, you don't end up having full maturation.

Penis doesn't grow to full size like it would.

Facial hair doesn't develop. Prostate growth doesn't happen as much, et cetera. So most notable, though,

about this is the fact that with DHG deficiency with intact testes and male testosterone levels,

you will still have male levels of performance, undoubtedly. So with this condition, the gonads

can still function and produce male levels of testosterone. Undoubtedly. So with this condition, the gonads can still function and produce male levels of testosterone

...