Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Huberman Lab

Scicomm Media

Science, Health & Fitness, Life Sciences

4.8 • 26.2K Ratings

🗓️ 8 July 2024

⏱️ 233 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

In this episode, my guest is Dr. Matthew Hill, Ph.D., a professor of cell biology and anatomy at the Hotchkiss Brain Institute at the University of Calgary and an expert on the biology of cannabis. We discuss how cannabis affects the brain to produce its psychoactive effects (feeling “high”), including altered time perception, focus, memory, appetite, and stress. We discuss how THC vs. cannabidiol (CBD) affects the brain, the effects of different routes of cannabis administration (e.g., smoking, vaping, edibles), high-potency THC, and whether cannabis is addictive. We discuss if there is a link between cannabis use and the development of psychosis, anxiety, bipolar depression, or schizophrenia. We discuss whether CBD has clinical benefits in regulating stress, promoting sleep, and treating certain diseases. We also discuss if there are real and consistent differences in the biological effects of different cannabis strains, if cannabis impacts hormones, and the uses of cannabis for the management of pain, stress, Post-traumatic stress disorder (PTSD), anxiety, and nausea. Listeners of this episode will get an up-to-date understanding of what is currently known about how cannabis affects the brain and body, including both its potential benefits and risks. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://www.eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman BetterHelp: https://betterhelp.com/huberman InsideTracker: https://insidetracker.com/huberman Timestamps 00:00:00 Dr. Matthew Hill 00:00:00 Sponsors: Eight Sleep, LMNT & BetterHelp 00:07:16 Cannabis, THC, Cannabidiol (CBD), Terpenes 00:12:08 Psychoactive Effects, Cannabis “High”; Time Perception 00:16:55 Cannabis & Brain, CB1 Receptor, Endocannabinoids 00:26:19 Endocannabinoids Types: Anandamide, 2-AG 00:33:46 “Munchies”, Cannabis & Appetite 00:42:17 Sponsor: AG1 00:44:06 THC & Anandamide, Pharmacology 00:52:37 THC & CB1 Receptors, Intoxication & Appetite 00:58:57 Cannabis & Focus, Memory 01:04:09 Routes of Administration, Concentration, Cannabis Research 01:15:12 Self-Regulation, Inhalation & THC, Tolerance; THC Concentrates 01:22:25 Sponsor: InsideTracker 01:23:36 Addiction & Cannabis, Cannabis Use Disorder 01:31:30 Cannabis Legalization & Use, Edibles & ER Visits 01:36:48 Oral Consumption, Edibles, Dosing & Time Course 01:41:12 Drug Testing & Cannabis, Exercise 01:46:04 Cannabis & Hormones, Gynecomastia, Sperm Quality 01:54:37 Cannabis & Pregnancy; Selling Recreational Cannabis 02:04:07 Vaping 02:07:05 Psychosis, Anxiety & Cannabis 02:17:17 Cannabis, Psychosis, Schizophrenia & Genetics 02:30:45 Cannabis Use & Schizophrenia, Manic Bipolar, THC Potency, Nicotine 02:40:37 Schizophrenia, Cannabis Legalization 02:45:06 Cannabis Strains, Indica, Sativa, Subjective Effects & Expectancy Bias 02:57:00 CBD, Pediatric Epilepsy, Adenosine 03:07:22 Entourage Effect; Placebo Effect, CBD & Doses 03:19:12 Cannabis Health Risks, Cardiovascular Risk, Schizophrenia 03:27:08 Cyclic Vomiting Syndrome & Hot Shower 03:31:30 Cannabis Benefits: Pain, Stress, Anxiety, Post-Traumatic Stress Disorder (PTSD) 03:40:18 Cannabis & Anxiety, Anandamide & Stress Response 03:45:55 Scientific Discussion, Clarification & Advancement 03:49:47 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer

Transcript

Click on a timestamp to play from that location

0:00.0	Welcome to the Huberman Lab Podcast, where we discuss science and science-based tools for everyday life.
0:06.0	I'm Andrew Huberman and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.
0:15.5	My guest today is Dr Matthew Hill.
0:17.8	Dr Matthew Hill is a professor of cell biology and anatomy at the University of Calgary.
0:23.0	His laboratory studies cannabis and its effects on stress, its effects on feeding, and its effects
0:28.4	on the behavioral impacts of cannabis exposure at different stages of development.
0:33.6	The origin of today's podcast episode is a bit unique,
0:36.2	so I'd like to share a little bit of that background with you.
0:39.0	Previously I did a solo episode of the Huberman Lab podcast about cannabis, the biology of
0:44.5	cannabis, some of its medical applications and uses, as well as some of its
0:48.3	potential harms. That episode came out several years ago now and remains a very popular episode.
0:53.7	It's had millions of views and millions of listens.
0:56.8	Several months ago, we posted a clip of that episode to X, formerly known as Twitter.
1:02.6	And Dr. Matthew Hill responded to that clip on X,
1:06.0	with criticism about the specific points made within that clip.
1:10.0	Most notably, my discussion of the data
1:12.0	that cannabis use can in some individuals cause psychosis.
1:16.5	He also took issue with some of the specific points I made in that clip related to potential differences in the biology of the effects of different strains of
1:24.5	cannabis, most notably Indica versus Sativa strains, and a few other points as
1:29.2	well. Now as somebody who's been in the field of science for several decades now, I'm very familiar with the fact that every field, every single field within science has debates within it, controversies, and sometimes outright battles. And to me that's part of what makes science interesting.
1:43.7	It's an evolving process.
1:45.1	It's something for which we should all be very curious to try and understand
	...

Transcript will be available on the free plan in -184 days. Upgrade to see the full transcript now.

Previous episode | Next episode

Disclaimer: The podcast and artwork embedded on this page are from Scicomm Media, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of Scicomm Media and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.