Hey, everybody. Welcome back to a flawless night. It's Monday 7 p.m., not 716. We're doing Iron Culture presented by Mass, and I'm here with a good Dr. Eric Holmes. And Dr. Eric Holmes, I've heard, I have it on good authority that you've been thinking a lot lately about metabolic stress.

I have.

Was it fair to say that it's frankly stressing you out a bit?

You know what?

I feel like it's requiring a lot of oxygen from me, but that I'm getting through it without it.

You know, so.

So metabolic stress, I mean, what in the world?

First of all, why do you care?

And second of all, should I?

And third of all, should the listener?

I think that is a great way of framing it.

Well, I will say that given our audience, I would suspect that a lot of people have encountered the term metabolic stress in the context of it being one of those big three

mechanisms for hypergraphy that the good doctor, uh, Schoenfeld has proposed way back when in 2010.

And, um, it's been repeated since then. Like, hey, so metabolic

stress is either causes hypertrophy, maybe independently. Drop to C word, which is big in research.

I know. Or maybe it has an additive effect on other on to hypertrophy, or maybe it just indirectly can impact hypertrophy, or some would claim it has no influence at all on hypertrophy.

But let me ask you this, Trex, how often when you hear people in kind of the evidence-based sphere talking about metabolic stress, do you think that they really know what they're saying when they say metabolic stress?

What percent?

Fifteen percent of the time.

I think that's pretty accurate.

I would have been okay with anywhere from 12 to 18 percent.

Oh, good.

...