The effects of betane supplementation on homocysteine and what I like to call the vasodilation brick wall.

Research has shown that betane supplementation may reduce the risk of cardiovascular disease as well as improve digestion and liver function.

One of the primary ways that facilitates a cardioprotective effect is proposed to be its acute and dose-dependent

effect on plasma homocysteine concentrations. So optimizing vasodilation isn't just about hammering

yourself with nitric oxide precursors. It's also about optimizing the clearance of vasoconstrictors or attenuating their activity.

An optimal approach to not just gym performance, but broad spectrum health accounts for all

angles, of my opinion.

And homocysteine is very impactful on blood pressure and cardiovascular health.

Elevated homocysteine impairs the clearance of something called asymmetric dimethyl

arginine, ADMA.

This is a biomarker that is assessed not commonly, but it is becoming more widely known

for its being a proxy for vasodilation potential, which we'll get into now.

Nitric oxide synthesis, NOS, or a family of enzymes catalyzing the production of nitric

oxide from L. Arginine.

ADMA is a naturally occurring endogenous inhibitor of nitric oxide synthase.

So ADMA competes with L. Arginine for Nas, nitric oxide synthase.

And as a result, the expression of nitric oxide decreases.

So almost think of it like a anti-androgen of sorts, you know, like anabolic steroid, you know, testosterone competing

for the androgen receptor. If you have an antigenrategor, it attenuates the capacity of testosterone

to do what it does and impart gene expression. So ADMA competes with arginine for

NOS. So by inhibiting nitric oxide formation, ADMA causes endothelial

dysfunction, vasoconstriction, elevation of blood pressure, and aggravation of atherosclerosis.

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