All right, so welcome back to the internet book of critical care.

I'm here at Adam Thomas and we're going to talk about serotonin syndrome.

Josh, this is one of my favorite toxidylose because it brings up tons of pathophysiology,

interactions, and management strategies.

So today we'll go over the overview of what is serotonin

syndrome, what populations you need to think about it in, and how do you need to keep it on your

radar for having a low index of suspicion. So let's get right into it. Josh, causes of

serotonin syndrome. Is it just overdose or are there other things that can happen? Yeah, so this is

tricky. So first of all, overdose is certainly one if you overdose on a serotonergic medication,

and this is more and more common with more and more folks on SSRIs.

And then the other ways that this can happen are an inference interaction of multiple

serotonergic medications, which I think might be more common.

And this can be confusing because this can even include some drugs that inhibit the metabolism of a

second drug, which is serotonergic, and then that interacts with a third drug that's also serotonergic.

So you can get some very complicated interactions.

You just hit Inception Level 1, 2, 3.

I like it.

It's terrible.

You've inserted a link, by the way, in the post having to Josh, about how sometimes if we don't know how this matrix bosom of interactions can be playing out in our patients, we can just insert it into

Medscape Drug Interaction Program and it'll do it for us. Yeah, this is a great place for

that program. You know, if you're seeing like a couple of Sartanergic medications and you're

like wondering, how are these things connected? Are there other medications that could be

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