The Science Behind Inflammation and Aging With Deinde and Debut CEO, Joshua Britton
Skincare Anarchy
Ekta et al.
4.2 • 2K Ratings
🗓️ 12 March 2025
⏱️ 29 minutes
🔗️ Recording | iTunes | RSS
🧾️ Download transcript
Summary
Inflammation isn't just about redness and irritation—it’s a driving force behind premature aging. In this episode of Skin Anarchy, host Ekta sits down with Joshua Britton, CEO of Deinde, to explore how inflammation accelerates skin aging and how cutting-edge biotechnology is changing the skincare game.
Britton, a scientist-turned-beauty entrepreneur, founded Deinde under the biotech powerhouse Debut, with a mission to bring lab-driven skincare to consumers. With a team of 80 scientists and a platform screening 50 billion molecules, Deinde is developing targeted solutions for inflammatory aging, a process where chronic, low-grade inflammation breaks down collagen, deepens wrinkles and worsens conditions like rosacea, eczema, and acne.
One of their breakthrough discoveries? Naringenin—a potent anti-inflammatory compound that outperforms niacinamide in reducing inflammatory markers by 15 times. Clinically tested at a precise 0.45% concentration, it significantly improves skin elasticity, reduces deep wrinkles, and restores baseline skin health—without the irritation caused by higher concentrations of traditional actives.
Britton also debunks skincare marketing myths, calling for science over hype. With trends like exosomes dominating the conversation, he emphasizes the importance of clinical validation over buzzwords, urging consumers to choose evidence-backed formulations over marketing gimmicks.
This episode is a must-listen for anyone looking to future-proof their skincare routine with biotech-driven solutions that work at the molecular level. Tune in to discover how Deinde is redefining the way we fight aging—starting with inflammation.
To learn more about Deinde, visit their website and social media. Don’t forget to subscribe to Skin Anarchy on Apple Podcasts, Spotify, or your preferred platform. Reach out to us through email with any questions.
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Transcript
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| 0:00.0 | Hey guys, welcome back to Skin Anarchy. This is EXA and I have such a wonderful brand that I'm going to introduce you guys to today. |
| 0:06.7 | And obviously we have the CEO, the mastermind behind it. But, you know, I just want to let everybody know that this conversation is going to be a lot about a topic that I think is now up and coming in the science of skin space, you know, which is this idea of inflammation |
| 0:22.9 | and what that really actually means for skin health. So I'm really excited to talk about that |
| 0:26.9 | with you guys. Without further ado, please welcome Joshua Britton, who's the CEO of Dende. Welcome, |
| 0:33.2 | Josh. I'm so excited to host you. I am so excited to be here. Thanks for having me. |
| 0:37.7 | And yeah, really excited to get into the science today behind Dende and what makes us so special. |
| 0:42.5 | So thanks for having me. |
| 0:43.9 | Yeah, let's go. |
| 0:45.5 | Yeah, no, I'd love to dive in. |
| 0:47.2 | I know that you're also, you know, behind Debutte, which is a bigger company. |
| 0:52.2 | And I'd love to learn a little bit about you, if you don't mind |
| 0:54.4 | about, you know, where Dende really started and where the idea came from to focus on, like, |
| 1:00.1 | inflammation when it comes to skin health. If you could kind of look at that. Yeah, that's a great one. |
| 1:04.9 | Yeah. So, you know, I transitioned out of academia to building a debut and, of course, Dende. |
| 1:13.0 | And the real reason behind that is, as you know, most science stays in the lab, right? |
| 1:17.9 | I think many people listening to this, many of the people and part of the team have worked on science for many, many, many years. |
| 1:23.6 | But it never makes its way out of the lab, into product, into people's homes and makes an impact. |
| 1:29.1 | So really start a debut with that. |
| 1:32.0 | And of course, the way we actually deliver the best science and the best formulations to the world is through Dende. |
| 1:40.4 | And like, Dende has a team now of 80 scientists dedicated to researching and creating novel ingredients through biotechnology. |
| 1:48.7 | And yeah, Dende was the thinking of how can we best and quickest bring these benefits to consumers that are truly effective and accessible to all. |
| 1:57.1 | And so, you know, we have this platform where we can screen 50 billion molecules to look at consumer needs. |
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