EP. 207: A new study on tirzepatide just dropped, and some obesity experts claim it confirms that the drug works only by reducing calories. After reading the full paper myself, I’ve got a different take. In this episode, I unpack what the study actually shows—like how tirzepatide increases fat oxidation without impacting metabolic adaptation—and why the “calories in, calories out” story doesn’t tell the whole truth. There’s more going on here, and you deserve the full picture. Topics Covered: Does tirzepatide help with metabolic health beyond calorie restriction leading to weight loss? How does it affect metabolic adaptation in people with obesity? Can it boost fat oxidation? Is the “calories in, calories out” model outdated for GLP-1s? What does this mean for long-term metabolic health? Sponsored By: Qualia | Go to qualialife.com/DRTYNA for up to 50% off your purchase and use code DRTYNA for an additional 15% Sundays | As a Listener of The Dr Tyna Show, you can Get 40% off your first order of Sundays. Go to sundaysfordogs.com/DRTYNA and use code DRTYNA at checkout. Liver Love | Go to https://store.drtyna.com/products/liverlove Use code DRTYNASHOW at checkout to save. LMNT | Get your free Sample Pack with any LMNT purchase at drinkLMNT.com/drtyna BIOptimizers | For an exclusive offer on MassZymes go to Bioptimizers.com/DRTYNA and use promo code DRTYNA On This Episode We Cover:  00:00:00 – Introduction  00:02:44 – Obesity study on GLP1s and weight loss 00:04:21 – Calories in vs. calories out 00:05:44 – Resting metabolic rate 00:09:25 – Metabolic adaptation during dieting 00:12:11 – Tirzepatide dosing in clinical studies 00:15:49 – Maintaining weight loss 00:18:15 – GLP1s &  increased fat oxidation 00:19:14 – GLP1 microdosing myths 00:26:06 – Metabolic rate drops vs. metabolic improvements 00:29:51 – Lessons from the Biggest Loser study 00:34:20 – Study Comparation 00:35:25 – Weight loss, inflammation, and aging 00:36:35 – Health autonomy  00:40:23 – Caloric restriction and the CALERIE study Studies Mentioned:  Tirzepatide Did Not Impact Metabolic Adaptation In People With Obesity, But Increased Fat Oxidation Persistent Metabolic Adaptation 6 Years After The Biggest Loser Competition Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) Show Links GLP-1s Done Right University Dr. Tyna’s Strength Corner Metabolic Revamp Toolkit + Masterclass Further Listening:  GLP1s Uncovered (Free Class) EP. 202 | The Fight for Affordable GLP1s & the Truth About Big Pharma | Dave Knapp Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.