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Paul Saladino MD podcast

250. When You Should Worry About LDL Cholesterol with Mike Fave

Paul Saladino MD podcast

Paul Saladino, MD

Medicine, Health & Fitness

4.82.7K Ratings

🗓️ 19 July 2024

⏱️ 136 minutes

🧾️ Download transcript

Summary

Today, Paul and Mike unpack their opinions about lipids. They talk about true risk for cardiovascular disease, primary versus secondary prevention, lipid lowering drugs, and share their thoughts on a recent podcast episode with Peter Attia.


*Produced by Mountain Valley Media


00:06:08 Blood markers & imaging techniques of metabolic function

00:14:38 Gene mutations

00:20:28 LDL & Plaque burden

00:27:23 Money in statins

00:31:38 Downsides of lowering LDL

01:21:23 The downsides of popular cholesterol lowering drugs

01:41:07 Should we fear heart attacks?

01:45:23 PCSK9 Inhibitors

01:52:43 Risk profile of Statins

01:53:02 Risk vs. reward of Ezetimibe

02:04:02 Primary vs. secondary prevention


Resources:

Debunking Sugar Claims: What Dr. Lustig Got Wrong On The Huberman Podcast:

https://www.youtube.com/watch?v=JcEmSgbMfco&t=2933s


Work With Mike: https://mikefave.com/


Transcript

Click on a timestamp to play from that location

0:00.0

There's no money for pharmaceutical companies in telling people to stop eating process junk.

0:04.5

On this week's podcast, I had an amazing discussion with my buddy Mike Fave, who's been on the

0:09.2

podcast before. This is his second appearance. We talked about lipids, cholesterol, cardiovascular disease risk in the setting of

0:16.8

insulin sensitivity, context for all of this, and whether you should be taking a drug to lower your

0:22.0

cholesterol.

0:23.0

Pempedoic acid, statins, a zethemibe, PCS-K9 inhibitors,

0:27.4

we break it all down in this technical podcast.

0:30.9

In some ways, this podcast is a follow-up to something I recently did with Derek for more plates, more dates.

0:35.6

He had me on his podcast after I reached out to him, after seeing a clip of him and Peter Otea talking

0:40.4

about cardiovascular disease risk in the setting of different levels of

0:43.6

LDLs. So I went on Derek's podcast to help him understand context regarding

0:48.1

familial hyper cholesterol lemia and why medallion randomizations may not be the

0:52.3

end all and be all when it comes to

0:53.5

lipid levels and cardiovascular disease risk. So I'm going to send this

0:56.7

podcast to Derek and show him some of these things which add context,

1:00.1

everything we're talking about in that and we go into much more detail in this

1:02.6

podcast about all the drugs, risk benefit, all cause mortality, etc. So if you have

1:07.4

questions about your cholesterol, maybe it's gone up when you decrease seed oils and increase saturated fats which automatically come with an animal-based diet butter, gee, tallow, steaks.

1:20.0

Then this podcast is for you. It's technical, but bear with us. You'll learn a lot and I'm going to do my best to put in all the references in the video and in the show notes. So hopefully this video is very valuable for you and if you have more questions about lipids, cardiovascular disease risk, or anything you'd like to see me

1:34.6

discuss in future podcasts, please put it in the comments.

1:37.2

On to the podcast with Mike Faith.

1:38.9

All right, Mike, Fave, thanks for coming back on the podcast, man.

...

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