606: The Future of Longevity Medicine with Dr. Charles Brenner
Age Less / Live More
Lucas Rockwood
4.8 • 1.1K Ratings
🗓️ 7 February 2024
⏱️ 40 minutes
🧾️ Download transcript
Summary
“I don’t know the meaning of life, but I know the purpose of life: to survive and procreate.” This quote was from a biologist on the podcast eight years ago, and it stuck with me because if he’s right, I’ve achieved my biological imperative and I’m now on borrowed time. While that may sound soulless and even nihilistic, it’s also a helpful frame (for me) as I attempt to make choices to optimize my life in the second half - my bonus time. On this week’s podcast, you’ll meet a researcher who debunks many pop longevity myths and also shares some compelling research around the supplement nicotinamide riboside. Will it make you live forever? No, but it might help you live better for the time you are here.
Listen and learn:
- Why “biological age” tests are inaccurate
- How we’re unlikely to experience “escape velocity”
- Metformin, rapamycin, and resveratrol debunked
- Why so-called longevity clinics giving TRT and HGH are almost certainly reducing - not extending - lifespan
Links
ABOUT OUR GUEST
Dr. Charles Brenner, the Alfred E. Mann Family Foundation Chair in Diabetes and Cancer Metabolism at City of Hope National Medical Center, discovered nicotinamide riboside (NR) as a crucial precursor to NAD+ in 2004 and a second NR-to-NAD+ conversion pathway in 2007, enhancing yeast cell lifespan. Currently, Dr. Brenner leads groundbreaking clinical trials on NR, focusing on its maternal and neonatal effects and translating animal model findings into safe, evidence-based clinical practices for human metabolic stress conditions.
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Transcript
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| 0:00.0 | I had a human biologist on the podcast about seven years ago who said something that stuck with me. |
| 0:07.0 | He said I can't tell you the meaning of life, but I can tell you the purpose of life and the purpose is to survive and to procreate to make more life. |
| 0:15.6 | Meaning our biological imperative, if you were to look at human behavior and how we live and what we do, it's really, really centered around, |
| 0:21.9 | don't die die make babies biological |
| 0:24.3 | imperative fulfilled and while that's kind of a depressing soulless way to look at |
| 0:28.8 | existence for me it's been really sobering and helpful to think about this phase of my life as being bonus time. |
| 0:35.8 | I am on borrowed time and what that means is the slow recovery after exercise, the gray hair in my beard, the wrinkles that I see forming on my face, |
| 0:46.8 | they make sense. |
| 0:47.8 | They make sense. |
| 0:48.8 | And hopefully I can make choices to make the most of this bonus, this extra chapter that I've been given. |
| 0:53.3 | Don't get me wrong, I think there's a big long runway in front of me, but I've thrown out the |
| 0:57.5 | idea that I will achieve escape velocity, that I will live forever, and I'm under the working assumption that most of us are going to live to our 80s and a lot of us into our 90s and very very few of us into our hundreds and with that |
| 1:12.8 | acceptance comes a great deal of freedom and also responsibility to |
| 1:17.7 | make choices. My guest on this week's podcast is on the forefront of |
| 1:21.4 | longevity research and he's really helped to debunk a lot of the |
| 1:25.2 | popular ideas that have been floating around and also leading into some of the better science |
| 1:30.3 | and unfortunately there still is no magic pill nor does it seem like there will be, but there are some interesting things to take a look at. |
| 1:36.5 | If you're new here, it's the Lucas Rockwood show. I'm a yoga teacher and trainer, a serial entrepreneur, and I'm a father of three three kids but firstly I'm a student. |
| 1:43.7 | I use this podcast as a way to research and explore health span how to live our best life |
| 1:49.3 | with the years that we have here. If you like the show, scroll down |
| 1:52.7 | and leave a rating and review in whatever app |
| 1:55.1 | you're listening on. |
... |
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