Hi there, it's Matt here and welcome back to the podcast.

Now in the last episode on Sleep and THC, we discussed the core relationship between cannabis and sleep and in that first

episode we learned a number of different things I described that cannabis and THC does come with some general

health risks. If you look at the data those range from cognitive and psychiatric issues to various health related issues.

Again, that's not to suggest that there aren't counter suggestions of health upsides.

And once more I have no horse in this race.

I'm not trying to suggest going one way or the other on this front.

But after speaking about those general health issues, we then explored sleep specifically.

And here we discussed the really quite fascinating historical narrative of cannabis and sleep and

medically at least it traced all the way back to the 1800s and there were two very intriguing doctors, Dr. O'Shaughnessy and then later, Dr. Klen dining,

whose observations really cemented in the medical archive at least the

How to put this the sleep-inducing effects of cannabis and hemp resin both in dogs as well as in their patients.

But you may remember that one of Klandininininin's patients that I referred to had a slightly different narrative.

One of his patients was a habitual user of cannabis, and he noted that that patient had developed a tolerance and as a consequence

his hemp resin that he was usually very confident in in terms of sleep induction seem to be ineffective in that

patient and I'm going to come back to that issue later today and then in that

previous episode I told you about how cannabis acts on the body's natural

canabonoid system and specifically targets the CB1 receptor and THC by way of targeting the CB1 receptor of the

canabenoid system produces the psychoactive part of cannabis, which is just a fancy way of saying.

It's THC acting on these CB1 receptors principally, but not exclusively,

that gets you that feeling of being high.

And you will recall in that previous episode that I said,

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