The Matt Walker Podcast

Embark on a celestial journey tonight as Matt guides you through the vast expanse of the night sky in this soothing sleep story. Prepare to travel amongst the stars, exploring the constellations that have captivated humanity for millennia. Imagine yourself lying comfortably beneath the heavens on a warm evening, the stars twinkling like distant fireflies. Feel the gentle night air as you connect with the awe and wonder felt by ancient civilizations who gazed upon these same cosmic patterns, w...

Transcribed - Published: 28 April 2025

This week, Matt dismantles the myth that REM sleep only benefits the mind by revealing its profound importance for physical health. While deep sleep handles some repair, Matt details how REM is crucial for peak testosterone and growth hormone release, vital for muscle, bone, libido, tissue repair, and metabolism. He explains that REM's characteristic muscle paralysis (atonia) isn't just for safety; it fosters physical recovery by enabling deep muscle relaxation, boosting blood flow, lowering ...

Transcribed - Published: 21 April 2025

In this latest AMA episode, Matt and Dr. Eti Ben Simon tackle even more listener questions regarding any and all aspects of sleep. Today, they discuss sleep tracker accuracy, noting that while nightly data isn't perfect (~75-85% accurate), weekly trends are reliable. Feeling exhausted despite good tracker metrics? Potential causes include fragmented sleep, circadian issues, undiagnosed disorders (like apnea), or tracker-induced anxiety (orthosomnia). Matt and Eti stress consulting a specialis...

Transcribed - Published: 14 April 2025

Dr. Cheri Mah returns to the podcast today to explore a few different topics including how circadian rhythms shape athletic performance. She notes that these 24-hour cycles regulate sleep, hormones, and core temperature, with peak physical capacity often occurring between 4-8 pm—when many world records are set. Dr. Mah also discusses chronotypes, showing how tailoring training to one’s natural rhythm can enhance results. She reveals research on circadian disruption in sports, notably ho...

Transcribed - Published: 7 April 2025

Find tranquility in a secret setting as Matt guides you through tonight's sleep story set in "The Twilight Garden." Meet Clara, the lamp keeper, who lovingly tends to the hundreds of lanterns that illuminate this hidden haven. On this particular evening, a grieving visitor arrives, seeking solace and a way to remember a lost loved one. As Clara shares the garden's quiet magic and the healing power of light, you'll be enveloped in the garden's peaceful atmosphere, filled with the scent of lave...

Transcribed - Published: 24 March 2025

In today’s episode, Matt challenges the notion that REM sleep is solely for the brain, revealing its broad impact on physical health. He delves into REM's role in regulating testosterone and growth hormone, crucial for muscle function. Our host also highlights how REM aids muscle recovery via paralysis, boosting blood flow and supporting protein synthesis. Beyond muscles, Matt explores REM's effects on temperature regulation and heart health by boosting heart rate variability and promoting st...

Transcribed - Published: 17 March 2025

Matt and Dr. Eti Ben Simon team up to answer more audience questions today, and begin by delving into the subjective experience of time during dreams, exploring how our perception stretches and compresses during REM sleep and whether we can hack our dreams. They also explain the cognitive, emotional, hormonal, and immunological consequences of pulling an all-nighter, highlighting the dramatic impact on memory consolidation, stress hormones, appetite regulation, and immune function. The cardio...

Transcribed - Published: 10 March 2025

Matt Walker welcomes Dr. Ranji Varghese back to the podcast today to complete the whole sleeping pill story by discussing newer sleeping pills, beyond benzos and Z-drugs. Together, they explore Melatonin receptor agonists (like Ramelteon) that signal sleep preparation, unlike sedating GABAergics. They also detail how DORAs inhibit the wakefulness-promoting orexin, how off-label options (ex. trazodone, low-dose doxepin) affect histamine, the risks and benefits of each. Dr. Varghese goes ...

Transcribed - Published: 3 March 2025

Escape into a world of untold stories with Matt as he guides you through tonight's sleep story set in "The Archive of Lost Letters." Meet Stephanie, the archivist, who tends to letters never sent, filled with unspoken confessions and unshared truths. Tonight, a visitor arrives, searching for a lost piece of himself. As Stephanie helps him uncover a forgotten letter, you'll be enveloped in the library's quiet atmosphere, filled with the scent of old parchment and the weight of unspoken words. ...

Transcribed - Published: 24 February 2025

This week Matt explores dreams, questioning if their specific content matters beyond the normal benefits of REM sleep. This episode examines dreaming's significance for creativity, memory integration, and its role as emotional first aid. The discussion then introduces a "hot off the press" study showing how dreams might help us shed unwanted memories, with insights into how REM sleep acts as a nocturnal soothing balm for emotional distress. The episode shares how REM sleep can take the ...

Transcribed - Published: 17 February 2025

In their latest AMA episode, Matt and Eti address listener questions ranging from "beauty sleep" to 3 AM awakenings. They explore the scientific evidence supporting sleep's crucial role in skin health and perceived attractiveness, citing studies on the effects of sleep deprivation. The cognitive benefits of napping are discussed, highlighting its ability to enhance learning and memory consolidation. They also delve into the remarkable neural activity of deep non-REM sleep, including synchroni...

Transcribed - Published: 10 February 2025

This week, Matt Walker dives into the world of the widely used sleeping pill, Ambien (Zolpidem). He explains how Ambien, a non-benzodiazepine sedative-hypnotic, works by targeting the brain's GABA receptors, specifically the alpha-1 subunit, to induce sleep. However, this comes with consequences. Matt highlights research by Dr. Marcos Frank showing that Ambien significantly impairs memory consolidation, essentially unwiring the brain's learning processes during sleep by approximately 50%.&nbs...

Transcribed - Published: 3 February 2025

This week, Matt Walker dives into the world of the widely used sleeping pill, Ambien (Zolpidem). He explains how Ambien, a non-benzodiazepine sedative-hypnotic, works by targeting the brain's GABA receptors, specifically the alpha-1 subunit, to induce sleep. However, this comes with consequences. Matt highlights research by Dr. Marcos Frank showing that Ambien significantly impairs memory consolidation, essentially unwiring the brain's learning processes during sleep by approximately 50%.&nbs...

Transcribed - Published: 3 February 2025

Settle into the embrace of your bed, feeling its comforting presence beneath you. This connection anchors you to the present, quieting the mind's chatter and creating a foundation for restful sleep. Tired of untrustworthy protein shakes? Show sponsor Puori prioritizes quality: hormone-free, GMO-free, and pesticide-free. Every batch is third-party tested for 200+ contaminants - you can even scan the QR code for lab results! Matt recommends the addictive dark chocolate flavor with 21g of p...

Transcribed - Published: 27 January 2025

Join Matt and renowned sleep scientist Dr. Cheri Mah today as they delve into the crucial connection between sleep and athletic performance. Dr. Mah's groundbreaking research at Stanford, including her famous basketball player sleep extension study (which revealed a 9% improvement in free throws and three-pointers!), demonstrates how prioritizing sleep can significantly enhance athletic abilities. In this fascinating episode, she discusses with Matt how sleep impacts not only physical recover...

Transcribed - Published: 20 January 2025

In his latest "Ask Me Anything" episode, Matt is once again joined by Dr. Eti Ben Simon to respond to a variety of audience questions, beginning with the role of AI in sleep medicine. Together, they explore how AI is currently being used to improve the accuracy and efficiency of sleep stage scoring, and how it shows promise in diagnosing sleep apnea and personalizing treatment plans. Matt highlights the potential for AI to integrate with smart home technology and predict an individual's risk ...

Transcribed - Published: 13 January 2025

Welcome back to a new episode of the Matt Walker Podcast, where we revisit the often-discussed topic of catch-up sleep. We delve into the complexities of weekend catch-up sleep, exploring a recent study of 91,000 participants that suggests a potential link between compensatory weekend sleep and a reduced risk of heart disease. While this news offers a glimmer of hope, it's crucial to understand this benefit within the context of existing research. Studies like that of Dr. Ken Wright at ...

Transcribed - Published: 6 January 2025

Matt Walker welcomes Dr. Ranji Varghese to the podcast this week for an in-depth conversation about sleep and prescription sleeping pills. A psychiatrist specializing in sleep medicine, Dr. Varghese begins by discussing his entry into the field which was sparked by a fascination with sleep and wake circadian rhythms. He goes on to highlight the Minnesota Regional Sleep Disorder Center's focus on parasomnias, particularly REM Sleep Behavior Disorder, emphasizing the intersection of neuroscienc...

Transcribed - Published: 23 December 2024

Embark on a calming journey to the Scottish Highlands in tonight's sleep story. Join Matt as he guides you through a tranquil landscape of rolling hills, sparkling lochs, and fragrant valleys. Let the soothing sounds of nature and the peaceful imagery lull you into a deep, restful sleep. This immersive experience is designed to ease your mind and help you unwind after a long day.Tonight's story offers a sanctuary from the whirlwind of everyday life, allowing you to release your worries and em...

Transcribed - Published: 16 December 2024

Dr. Charan Ranganath returns to explore the complexities of human memory with Matt here today. Together, they delve into memory's architecture, examining how sleep, trauma, and AI impact its function. The discussion covers episodic and semantic memory, emphasizing the role of sleep in memory consolidation and challenging the traditional "archive" model with Dr. Ranganath proposing a dynamic web of interconnected associations instead. The conversation then shifts to trauma's effects, focu...

Transcribed - Published: 9 December 2024

Matt and Eti’s latest AMA episode begins with an exploration of the fascinating relationship between circadian rhythms and medication effectiveness. Discover how this internal 24-hour clock influences drug absorption, distribution, metabolism, and excretion, impacting treatment outcomes. The episode then delves into chronotherapy, revealing how timing can optimize medication efficacy and minimize side effects for conditions like high cholesterol and high blood pressure. Together, our hos...

Transcribed - Published: 2 December 2024

Join Matt today as he explores the fascinating intersection of sleep, metabolism, and weight management, delving into the science of dual orexin receptor antagonists (DORAs). This episode dissects a groundbreaking study on suvorexant (Belsomra), an FDA-approved insomnia medication, and its potential to enhance fat burning during sleep. Matt unpacks the role of orexin, a neuropeptide crucial for wakefulness, and explains how DORAs work by targeting orexin receptors to promote natural sleep.&nb...

Transcribed - Published: 25 November 2024

Escape the everyday and drift off to dreamland with Matt’s guided sleep story. Together, we'll journey through tranquil landscapes, from moonlit valleys to sun-dappled forests, letting the soothing sounds and imagery lull you into a peaceful slumber. This is a sleep story designed to ease your mind and gently guide you into a deep, restful sleep. If you find yourself struggling to unwind after a long day, allow this narrative to transport you to a place of tranquility and calm. Release your w...

Transcribed - Published: 18 November 2024

Matt dives deep into the science of memory with renowned neuroscientist Dr. Charan Ranganath, author of Why We Remember: Unlocking Memory's Power to Hold On to What Matters in today’s episode. Together, they explore the complex relationship between memory and the brain, touching on the roles of emotional significance, context, and even neuromodulators like dopamine in helping our brains decide which memories to retain and which to discard. Dr. Ranganath shares his unique journey into mem...

Transcribed - Published: 11 November 2024

In Matt’s latest installment of his "Ask Me Anything" series, he once again joins forces with Dr. Eti Ben Simon to address a wide spectrum of listener questions. Beginning with a dive into the fascinating connections between sleep and medication effects, they unpack the ways various medications can impact sleep quality and patterns, from increasing alertness to potentially triggering vivid dreams or insomnia. Eti also brings a unique perspective on how different medications influence REM slee...

Transcribed - Published: 4 November 2024

Matt returns this week to unpack the complexities of narcolepsy, a neurological sleep disorder often misunderstood and misdiagnosed. He starts by defining narcolepsy, explaining its profound impact on brain and body functioning and its chronic nature, which often diminishes patients' quality of life. Narcolepsy affects about 1 in every 2,000 people, yet most go undiagnosed due to limited awareness and medical training on sleep disorders. With a closer look at the causes, Matt explores how the...

Transcribed - Published: 28 October 2024

Matt revisits the concept of "sleep divorce," or "sleep separation" in this latest episode, examining its effects on relationships and well-being. He cites studies showing that up to one in four couples in the U.S. and U.K. sleep in separate rooms, a statistic often underestimated due to stigma. While many fear that sleeping apart harms intimacy, Matt presents data indicating that it can actually enhance sleep quality and intimacy by promoting better-rested bodies and increasing hormones like...

Transcribed - Published: 14 October 2024

Matt and Dr. Eti Ben Simon return today for yet another AMA session where they dive into even more fascinating and often quirky sleep questions that have been submitted by listeners. In this installment, our duo explores the evolutionary puzzle of why we sleep, despite the apparent risks it poses for survival. They also share insights into how early organisms, like earthworms, exhibit sleep-like states, which raises the question: did wakefulness evolve from sleep?As the episode continues, the...

Transcribed - Published: 7 October 2024

Matt Walker welcomes Dr. Jessica Lunsford-Avery, an Associate Professor in Psychiatry and Behavioral Sciences at Duke University to the podcast today. Dr. Lunsford-Avery, a clinical psychologist, delves into the crucial link between sleep and mental health in children with ADHD. Her groundbreaking research explores how sleep impacts daytime impairment in ADHD, focusing on cognitive behavioral therapies to improve both sleep quality and ADHD symptoms. Their discussion highlights the critical n...

Transcribed - Published: 23 September 2024

Dr. William “Bill” Jagust, renowned expert in brain science and Alzheimer’s research - and one of the reasons Matt chose to move to UC Berkeley - joins our host today for an in-depth discussion on aging, cognitive decline, and the critical role of neuroimaging, with some sleep talk woven in as well. Dr. Jagust shares groundbreaking insights into how PET scans can detect amyloid and tau proteins in the brain—two key contributors to Alzheimer’s disease—years before symptoms emerge. Together wit...

Transcribed - Published: 9 September 2024

In this latest AMA episode, Matt and Eti are back to tackle listener questions about naps and sleepwalking this time around. They begin by delving into the intricacies of power naps and their impact on brain function and sleep health, and go on to discuss the optimal timing and duration for naps, emphasizing that a balance between benefits and drawbacks is crucial. Shorter naps of 10-20 minutes are highlighted for their ability to boost alertness and focus with minimal sleep inertia. Con...

Transcribed - Published: 2 September 2024

Dr. Wendy Troxel returns to the podcast today to discuss the significant impact of sleep on relationships and mental health with Matt. Offering actionable strategies for couples facing inevitable sleep disruptions, Dr. Troxel emphasizes the importance of communication, suggesting that couples anticipate sleep challenges, share responsibilities, and use tools like the "slangry" label to recognize and manage sleep-deprived behaviors. She also highlights the importance of timing conversations an...

Transcribed - Published: 26 August 2024

This week, Matt shines his spotlight on the intriguing topic of melatonin use for individuals living with autism spectrum disorder (ASD). While melatonin has been discussed in previous episodes in relation to sleep enhancement and antioxidant properties, today's focus is on a recent meta-analysis that examines its effectiveness in treating sleep disorders specifically in those with ASD. This deep dive is prompted by new data and the pervasive sleep challenges faced by individuals with autism,...

Transcribed - Published: 12 August 2024

In yet another informative and entertaining AMA episode, Matt and Doctor Eti Ben-Simon delve into the variety of sleep-related questions uppermost in listeners’ minds . Matt begins by explaining that THC, the main psychoactive component in cannabis, can help individuals fall asleep initially but disrupts sleep patterns and circadian rhythms with chronic use. This can lead to increased brain temperature, tolerance, dependence, and decreased REM sleep, impacting emotional regulation and overall...

Transcribed - Published: 5 August 2024

The Science of Shared Sleep: Dr. Wendy Troxel on Bedtime and RelationshipsThis week, Matt is joined by Dr. Wendy Troxel the celebrated sleep and behavioral scientist whose book, Sharing the Covers: Every Couple's Guide to Better Sleep, highlights the significant impact of sleep on relationships. Revealing that 61% of adults sleep with a partner, Dr. Troxel emphasizes the often-overlooked social aspect of sleep and its implications for couple dynamics. As she notes, sleep arrangements have his...

Transcribed - Published: 29 July 2024

Matt and Dr. Eti Ben Simon are back today to answer more of your excellent questions with their latest AMA installment - #8!They begin by delving into the intriguing world of lucid dreaming, explaining how it enables dreamers to become aware and even control their dreams, and move on to discussing the scientific methods used to study lucid dreaming, such as using eye movements as a form of Morse code to communicate with researchers. Through studies involving MRI scans, scientists have validat...

Transcribed - Published: 15 July 2024

Matt continues his series on the impact of cannabis, THC, and CBD upon sleep this week with an examination into the intricacies of cannabidiol (CBD), which, unlike its psychoactive counterpart THC, does not induce a high but is recognized for its potential therapeutic effects. While studies suggest that CBD may aid in alleviating anxiety, movement disorders, pain, and addiction, in this episode, our host focuses on exploring CBD's potential influence on sleep quality while examining its bioch...

Transcribed - Published: 1 July 2024

In this week’s intriguing episode, Matt delves into the topic of precognitive dreams, exploring the idea that some people can predict future events through their dreams. He explains that while this concept might seem appealing, it is actually a result of statistical chance. With around 8 billion people in the world each having multiple dreams per night, the sheer number of dreams increases the likelihood of coincidental matches between dreams and real-life events. Matt also discusses a g...

Transcribed - Published: 18 June 2024

In this 7th installment of their AMA series, Matt Walker and Dr. Eti Ben Simon dive into strategies for improving deep non-REM sleep. They highlight the benefits of vigorous exercise, citing a study by Kaspar Vogt that shows how exercise enhances the quality and stability of deep sleep. Additionally, they discuss how temperature manipulations, like using high heat capacity mattresses, can also improve sleep quality. Interesting insights include findings that intense exercise can improve deep ...

Transcribed - Published: 10 June 2024

Dr. Chris Barnes, renowned Michael G. Foster Endowed Professor of Management at the Foster School of Business, University of Washington, returns to the podcast today to continue his discussion with Matt regarding sleep's impact on business productivity. This time around, Dr. Barnes shares research indicating that sleep-deprived leaders exhibit abusive supervision, reducing employee engagement and productivity. Exploring sleep's broader implications on corporate culture and economic perfo...

Transcribed - Published: 3 June 2024

Matt continues his exploration into the intricate link between cannabis and sleep, focusing on THC in this second installment, beginning with a reminder to listeners of the historical insights from doctors like O'Shaughnessy and Clendinning in the 1800s regarding cannabis's sleep-inducing effects. He shifts to how THC affects sleep today, noting that while it initially reduces sleep onset time and early night awakenings, chronic use worsens sleep quality, leading to frequent disruptions, espe...

Transcribed - Published: 20 May 2024

Matt and Eti team up again today for another entertaining and informative AMA episode. This time around, they dive into the intriguing world of lunar cycles and their potential influence on sleep patterns and dreams. From ancient beliefs to modern scientific findings, our duo unpacks the subtle yet fascinating impact of the moon. They then go on to explore the calming effects of weighted blankets on children and adults alike, revealing how deep touch pressure therapy enhances sleep quality an...

Transcribed - Published: 13 May 2024

Dr. Chris Barnes from the University of Washington's Foster School of Business joins Matt to discuss the often overlooked importance of sleep in boosting workplace productivity and ethical decision-making. Together, they delve into how sleep deprivation affects job performance, the impact sufficient sleep has on business environments and organizational success, and the hidden costs of sleep loss.Dr. Barnes presents compelling evidence on how businesses can use sleep as a strategic asset to cr...

Transcribed - Published: 6 May 2024

Matt introduces his series examining the complex relationship between sleep and cannabis, exploring both the historical context and contemporary scientific perspectives. The narrative begins with Dr. W.B. O'Shaughnessy's canine experiments in 1849, tracing the evolution to the foundational work on cannabis for sleep conducted by Drs. Clendinning and Bradbury. Despite anecdotal reports suggesting cannabis enhances sleep, the scenario is complicated by factors such as regulatory constraints, va...

Transcribed - Published: 22 April 2024

This week, Matt dives deep into the complexities of REM Sleep Behavior Disorder (RBD), a condition where individuals physically act out their dreams due to the absence of normal muscle paralysis during REM sleep. He meticulously breaks down the mechanisms of normal REM sleep, where the brainstem induces muscle atonia to prevent dream enactment, contrasting it with the failure of this system in RBD cases. Further expanding on the topic, Matt explores the etiology, diagnosis, treatment opt...

Transcribed - Published: 8 April 2024

Eti is back for another AMA episode with Matt to answer questions that have been submitted over the last little while. Today’s installment dives into a number of topics including the intricate relationship between sleep and pregnancy, exploring how sleep disturbances impact pregnant women and the postnatal period. Additionally, the hormone prolactin, essential for milk production, is highlighted for its sleep-promoting benefits during the postnatal phase, illustrating nature's intricate balan...

Transcribed - Published: 1 April 2024

In today's podcast episode, Matt welcomes back Dr. Michael Gradisar to delve into the evolving understanding of screens and sleep. Initially holding the belief in the detrimental effect of screen light on sleep, Matt finds this notion challenged by Dr. Gradisar's research, which emphasizes a more nuanced perspective. Their discussion highlights the shift from simplistic concerns about screen use to acknowledging the multifaceted influences on sleep, including content and individual difference...

Transcribed - Published: 25 March 2024

Matt explores menopause and sleep disturbances today, noting the impact of hormonal changes, including a drop in estrogen and progesterone, and the role of hot flashes in disturbed sleep. He enumerates different types of sleep impairments related to menopause such as insomnia, sleep-disordered breathing, restless leg syndrome, and various sleep stage disruptions. Treatment options are discussed, with an emphasis on hormone replacement therapy, though controversy surrounding this approach is a...

Transcribed - Published: 11 March 2024

It’s another AMA episode and Dr. Eti Ben Simon returns to not only share some of her own sleep routines, but also to help listeners gain a rare insight into Matt's personal sleep habits as they respond to a listener’s query. Renowned for not sharing much, if anything, regarding what he considers his “boring” self, Matt is coaxed into offering a candid exploration of his bedtime routines, shedding light on both his successes and challenges in achieving optimal rest. From his dedication to regu...

Transcribed - Published: 4 March 2024

Matt Walker welcomes his dear friend, the epic sleep researcher and clinician, Dr. Michael Gradisar, to the podcast to join him in exploring the profound influence of light on sleep quality. Dr. Gradisar's groundbreaking research and clinical proficiency in pediatric sleep disorders and circadian rhythm disruptions have reshaped the field, guiding both scientific comprehension and practical interventions. His conversation with Matt here today delves into the intricate interplay among light ex...

Transcribed - Published: 26 February 2024