#797: Dr. Keith Baar, UC Davis — Simple Exercises That Can Repair Tendons (Tennis Elbow, etc.), Collagen Fact vs. Fiction, Isometrics vs. Eccentrics, JAK Inhibitors, Growth Hormone vs. IGF-1, The Anti-RICE Protocol, and How to Use Load as an Anti-Inflammatory

The Tim Ferriss Show

Tim Ferriss: Bestselling Author, Human Guinea Pig

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4.6 • 17.4K Ratings

🗓️ 25 February 2025

⏱️ 119 minutes

🔗️ Recording | iTunes | RSS

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Summary

Dr. Keith Baar is a Professor at the University of California, Davis in the Department of Physiology and Membrane Biology. During his Ph.D. studies, his research revealed that mechanical strain on muscle fibers activates the mammalian target of rapamycin (mTOR) signaling pathway, a crucial regulator of muscular hypertrophy. Subsequently, he studied the molecular dynamics of skeletal muscle adaptation to endurance training under the guidance of Dr. John Holloszy, a legend in the field of exercise physiology, considered the father of modern exercise biochemistry. Building on all of this experience, he conducted research into tendon health and the potential for engineering ligaments, which could have implications for treatment and recovery from injuries.

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Transcript

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0:00.0	Hello, boys and girls, ladies and germs. This is Tim Ferriss. Welcome to another and very detailed, very practical episode of the Tim Ferriss show. My guest today is Dr. Keith Barr. He is a professor at the University of California, Davis, in the Department of Physiology and Membrane Biology. We get into so many facets of exercise, what you can use today that is counterintuitive.
0:25.0	I had my mind blown.
0:26.8	I took so many notes.
0:27.7	We talked about isometric exercise for tendon health, optimizing different protocols, debunking
0:34.4	on some level eccentric training, specifically for connective tissue, how to load post-injury
0:39.9	or surgery, collagen supplementation, things like BPC-157, pharmaceutical impacts on tendons,
0:46.5	estrogen's role in tendon health and strength, mitochondria, ketogenic diet, longevity,
0:52.1	inflammation, and taking a balanced perspective on all of these
0:55.5	things. How do you use them? We get into exact training protocols that rock climbers use. It is an
1:01.6	amazing episode, and that's not because of me. It's because of Keith. So let me give you a quick bio,
1:06.7	and then we'll hop right into it. During his PhD studies, his research revealed that the mechanical
1:11.3	strain on muscle fibers activates the mammalian target of rapamycin. Some of you may know that as
1:16.7	mTOR, signaling pathway, a crucial regulator of muscular hypertrophy or muscle growth. So he knows a lot
1:22.7	about muscle growth. He's been a strength training coach as well. Subsequently, he studied the
1:27.2	molecular dynamics of
1:28.3	skeletal muscle adaptation to endurance training under the guidance of Dr. John Halazi, a legend in the
1:33.7	field of exercise physiology, considered the father of modern exercise biochemistry. Building on all of this,
1:40.0	he conducted research into tendon health and the potential for engineering ligaments that is creating
1:45.1	ligaments in the lab upon which he can test all sorts of things, which could also have
1:49.6	implications for treatment and recovery from injuries. Dr. Barr now runs the functional
1:54.0	molecular biology lab at UC Davis. His lab's work ranges from studying molecular changes in
1:59.3	ourselves to conducting studies to affect
	...

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