4.5 • 774 Ratings
🗓️ 8 April 2024
⏱️ 88 minutes
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Irritable bowel syndrome (IBS) is often diagnosed when symptoms don’t have an obvious cause. But anyone with IBS symptoms knows it’s a REAL condition. Dr. Alex Ford and I are share what irritable bowel syndrome treatments are getting wrong—and how to start feeling better.
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➡️The Pros & Pitfalls of Getting Tested for IBS
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➡️IBS: What It Is and How to Treat It
https://drruscio.com/what-is-ibs/
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00:00 Intro
04:40 What is IBS?
12:00 The problem with restrictive diets
14:35 Prevalence of SIBO in IBS patients
21:06 The gut-brain connection
25:25 Antidepressant effects on the gut
33:30 Do probiotics work for IBS?
40:28 IBS symptoms
47:06 Treatment options
Ford’s Research
📉Efficacy of Probiotics in IBS: https://pubmed.ncbi.nlm.nih.gov/37541528/
📉Antibiotics and Probiotics for IBS: https://pubmed.ncbi.nlm.nih.gov/37184752/
📉Amitriptyline at Low-Dose and Titrated for IBS as Second-Line Treatment in primary care: https://pubmed.ncbi.nlm.nih.gov/37858323/
📉Disorders of gut-brain interaction: https://pubmed.ncbi.nlm.nih.gov/35781806/
📉Rome IV Criteria: https://theromefoundation.org/rome-iv/rome-iv-criteria/
📉Global prevalence of IBS according to Rome III or IV criteria: https://pubmed.ncbi.nlm.nih.gov/32702295/
📉IBS and the Gut Microbiome: A Review: https://pubmed.ncbi.nlm.nih.gov/37048642/
📉Lactobacillus acidophilus NCFM affects colonic mucosal opioid receptor expression: https://pubmed.ncbi.nlm.nih.gov/24853043/
📉Interactions between symptoms and psychological status in IBS: https://pubmed.ncbi.nlm.nih.gov/36178333/
📉Probiotics fortify intestinal barrier function: https://pubmed.ncbi.nlm.nih.gov/37168869/
📉Probiotics for Preventing and Treating SIBO: https://pubmed.ncbi.nlm.nih.gov/28267052/
📉The effects of probiotics on constipation in adults: https://pubmed.ncbi.nlm.nih.gov/32005532/
📉The effect of multistrain probiotics on constipation in the elderly: https://pubmed.ncbi.nlm.nih.gov/35927504/
📉Efficacy of probiotics, prebiotics and synbiotics in IBS: https://pubmed.ncbi.nlm.nih.gov/37772692/
📉Outcome-Specific Efficacy of Different Probiotic Strains in IBS: https://pubmed.ncbi.nlm.nih.gov/37686889/
📉Strain-specific and outcome-specific efficacy of probiotics for IBS: https://pubmed.ncbi.nlm.nih.gov/34712929/
📉Efficacy of probiotics, prebiotics and synbiotics in IBS: https://pubmed.ncbi.nlm.nih.gov/37772692/
📉Efficacy of a low FODMAP diet in IBS: https://pubmed.ncbi.nlm.nih.gov/34376515/
📉Dietary glutamine supplements for post infectious IBS: https://pubmed.ncbi.nlm.nih.gov/30108163/
📉Peppermint oil for IBS: https://pubmed.ncbi.nlm.nih.gov/24100754/
📉Efficacy and Safety of Peppermint Oil in [...] Patients With IBS: https://pubmed.ncbi.nlm.nih.gov/31470006/
📉The IBS Outcome Study (IBSOS): https://pubmed.ncbi.nlm.nih.gov/22846389/
📉Treatments for diarrhea-predominant IBS: https://pubmed.ncbi.nlm.nih.gov/30194692/
📉Comparing probiotic and drug interventions in IBS: https://pubmed.ncbi.nlm.nih.gov/35848115/
📉Probiotics, prebiotics, and low FODMAP diet for IBS: https://pubmed.ncbi.nlm.nih.gov/30935559/
📉Anti-inflammatory effect of amitriptyline in a rat model of acetic acid-induced colitis: the involvement of the TLR4/NF-kB signaling pathway: https://pubmed.ncbi.nlm.nih.gov/33336463/
📉An Investigation on in vitro and in vivo Antimicrobial Properties of the Antidepressant: Amitriptyline Hydrochloride: https://pubmed.ncbi.nlm.nih.gov/24031539/
📉Amitriptyline modifies the visceral hypersensitivity response to acute stress in the IBS: https://pubmed.ncbi.nlm.nih.gov/19076934/
📉Effect of a tricyclic antidepressant on small intestinal motility in health and diarrhea-predominant IBS: https://pubmed.ncbi.nlm.nih.gov/7821126/
📉Recurrence of depression after discontinuation of long-term amitriptyline treatment: https://pubmed.ncbi.nlm.nih.gov/6800270/
📉Long-term amitriptyline in chronic depression: https://pubmed.ncbi.nlm.nih.gov/3894196/
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DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.
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0:00.0 | Welcome to Dr. Rucho Radio, providing practical and science-based solutions to feeling your best. |
0:14.8 | To stay up to date on the latest topics, as well as all of our prior episodes, make sure to subscribe in your podcast player. |
0:22.2 | For weekly updates, visit Dr.ruciot.com. |
0:25.8 | Hey, everyone. Today I spoke with Dr. Alex Ford. |
0:29.5 | He came recommended from Dr. Michael Kimmelary, who's over at the Mayo Clinic. |
0:34.6 | Dr. Alex Ford is a researcher in IBS, and he's recently authored a meta-analysis on |
0:41.7 | probiotics for IBS. His accolades are fairly impressive. He's a professor of gastroenterology at the |
0:48.4 | University of Leeds. He's a consultant of gastroenterology at Spire Leeds Hospital. |
0:55.2 | He's the associated editor of the Journal of Elementary Pharmacology and Therapeutics. |
1:01.0 | He focuses on IBS, functional dyspepsia, indigestion, disorders of the gut-brain access. |
1:08.2 | And we'll talk a lot about this today, diagnostic testing and obviously |
1:12.9 | publishing research, of which he's published a number of menanalyses on probiotics amongst other |
1:19.2 | therapies like drug therapy, like peppermint oil, so a very nice breath of areas that he focuses. |
1:28.4 | He's been published in the Journal of the American Medical Association, |
1:32.0 | the BMJ, the journal Gastroenterology, the journal Gut, |
1:35.0 | and the American Journal of Gastroenterology also. |
1:38.0 | So just a wealth of knowledge and experience as it pertains to research. |
1:43.2 | Today we discuss IBS and how we should be thinking |
1:47.7 | about that diagnosis and what that means differently from sort of a waste basket diagnosis |
1:54.6 | of exclusion to something that's more a disorder of the gut and the brain. So we go through this, the gut microbiome, |
2:06.2 | CBO. We also discuss a drug that I think if you've been struggling with digestive symptoms, |
2:14.3 | whether you're attributing those to Cbo, dysbiosis, if you're having |
... |
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