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Nature Podcast

AI-designed antivenoms could help treat lethal snakebites

Nature Podcast

[email protected]

Science, News, Technology

4.4 β€’ 859 Ratings

πŸ—“οΈ 15 January 2025

⏱️ 35 minutes

🧾️ Download transcript

Summary

00:46 Designing new antivenoms to treat snakebites


Researchers have shown that machine learning can quickly design antivenoms that are effective against lethal snake-toxins, which they hope will help tackle a serious public health issue. Thousands of people die as a result of snakebites each year, but treatment options are limited, expensive and often difficult to access in the resource-poor settings where most bites occur. The computer-aided approach allowed researchers to design two proteins that provided near total protection against individual snake toxins in mouse experiments. While limited in scope, the team behind the work believe these results demonstrate the promise of the approach in designing effective and cheaper treatments for use in humans.


Research Article: VΓ‘zquez Torres et al.



11:28 Research Highlights

How male wasp spiders use hairs on their legs to sniff out mates, and how noradrenaline drives waves of cleansing fluid through the brain.


Research Highlight: ​​​​​​​Male spiders smell with their legs

Research Highlight: ​​​​​​​How the brain cleans itself during deep sleep



13:53 Earth breaches 1.5 Β°C climate limit for the first time

News broke last week that in 2024, Earth’s average temperature climbed to more than 1.5 Β°C above pre-industrial levels for the first time. Although this is only a single year so far, we discuss what breaking this significant threshold means for the 2015 Paris climate agreement and what climate scientists understand about the speed that Earth is heating up.  


Nature: ​​​​​​​Earth breaches 1.5 Β°C climate limit for the first time: what does it mean?



23:39 Briefing Chat

NASA delays deciding its strategy for collecting and returning Mars rocks to Earth, and why papers on a handful of bacterial species dominate the scientific literature.


Nature: ​​​​​​​NASA still has no plan for how to bring precious Mars rocks to Earth

Nature: ​​​​​​​These are the 20 most-studied bacteria β€” the majority have been ignored


Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.



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Transcript

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0:00.0

Welcome to Breakthroughs with Pfizer UK, the podcast where Pfizer invites experts from across the pharmaceutical industry to discuss the most pressing healthcare topics.

0:10.7

What is the biggest thing that saved the most lives in terms of public health ever? It is clean water. And the second thing is vaccination.

0:18.3

The science is really exciting because we're still learning about it all the time.

0:23.5

As you are tricking the body's immune system.

0:27.1

Listen and follow wherever you get your podcast.

0:34.3

Nature.

0:36.7

An experiment.

0:38.5

Why is it like so far? Like it sounds so simple. In an experiment, I don't know yet.

0:40.5

Why is it like so far?

0:41.7

Like, it sounds so simple.

0:43.2

They had no idea.

0:44.4

But now the data's... I find this not only refreshing, but at some level astounding.

0:52.2

Nature.

0:57.8

Welcome back to the nature podcast.

1:03.5

This week, a computational method for making life-saving anti-venoms.

1:08.1

And news that Earth's temperature has breached a significant climate threshold.

1:09.6

I'm Lizzie Gibney.

1:10.7

And I'm Benjamin Thompson.

1:25.1

There's a neglected tropical disease that affects millions of folk around the world and is estimated to kill over 100,000 people each year and cause long-term

1:30.5

health impacts for many more. The WHO listed it as a highest priority neglected tropical disease

1:37.4

back in 2017. Now, I'm sure you're trying to figure out what it might be, and the answer may surprise you.

1:45.2

It's snake bites, specifically the bites of venomous snakes of various species.

...

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