Antihypertensive Drug Interactions Podcast – Episode 316

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5 • 716 Ratings

🗓️ 29 February 2024

⏱️ 14 minutes

🔗️ Recording | iTunes | RSS

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Summary

On this podcast episode, I discuss some of the most common antihypertensive drug interactions you need to know.

One major interaction I discuss is the trifecta of a diuretic, an ACE or ARB, and an NSAID. This combination significantly increases the risk for acute renal failure.

Nitrates aren't classically referred to as an antihypertensive but they can definitely cause some problems when combined with PDE5 Inhibitors.

Lithium can interact with 3 blood pressure medication classes. ACEIs, ARBs, and diuretics can all increase the risk for lithium toxicity.

Transcript

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0:00.0	Hey all, welcome back to the Real Life Pharmacology podcast today. I've got a bit of a special
0:06.5	episode for you here. This was per request of someone. I just wanted to know a little bit more
0:12.3	about drug interactions, so that's definitely what I'm going to cover today. If you would, definitely
0:17.7	go to Real Life Pharmacology.com. Get your free 31-page PDF on the top 200 drugs.
0:24.0	If you're taking pharmacology classes or if you're out practicing in the real world,
0:28.2	it's a great refresher.
0:29.7	Some of the things that I've come across in practice,
0:33.3	as well as things that I've seen on board exams as well as pharmacology exams.
0:38.6	So definitely stuff that you should probably know and have memorized if you're studying
0:44.0	pharmacology.
0:44.9	So again, simply an email.
0:46.3	We'll get you access to that at real-life pharmacology.com.
0:49.9	It's our top 200 study guide.
0:53.3	All right.
0:59.2	So let's get into the podcast today, which I said is going to be a little bit different.
1:10.0	I'm going to go over my top 10 drug interactions surrounding anti-hypertensive medications.
1:14.1	So those commonly used blood pressure medications wanted to give you guys some things to look out for in practice as far as drug interactions go. And then, of course,
1:21.4	a lot of these will show up on board exams as well. So I've got them in no particular order. Some are maybe less common,
1:31.5	but more severe, and some are maybe more common but less severe. But let's go. So ACE inhibitors,
1:41.1	diuretics, and insets. I've heard this called kind of a triple no-no. Ideally, we should avoid this
1:51.6	three-drug combination if possible. The reason being mechanistically, if you think about the way
2:00.1	aces and insides affect kind of that flow into the kidney.
	...

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