Beyond Ozempic: The Probiotic That Finally Stops Chocolate (& Food) Binges. Join Our Science Trial. (#72)
The Kevin Rose Show
Kevin Rose
4.9 • 2.1K Ratings
🗓️ 28 October 2024
⏱️ 32 minutes
🧾️ Download transcript
Summary
Friends,
I recently sat down with Dr. Colleen Cutcliffe, CEO of Pendulum Therapeutics, for a discussion about probiotics, metabolism, and a potential natural alternative to GLP-1 drugs like Ozempic. Here's why I'm excited to share this with you...
The Backstory
A month ago, I ran into a friend who had slimmed down and was looking fit. These days, I’ve had a good dozen or so friends lose weight with GLP-1 drugs, so I was surprised when she told me it wasn’t Ozempic but Pendulum's new GLP-1 probiotic. Her chocolate cravings (her usual downfall) had changed entirely. Instead of demolishing a whole bar, she could have one bite and walk away satisfied.
I've known Pendulum for years (we invested at True), and I've personally used their glucose control product with great success. However, I had lost touch with Colleen and didn’t realize they had a new GLP-1 product — so I asked her to come on the podcast and discuss it.
Note: Peter Attia did a much longer and more thorough deep-dive with Colleen, found here
What Makes This Different?
In my interview with Colleen, she explained how their probiotic actually helps your body produce its own GLP-1 hormone naturally. The science is fascinating – they've identified specific strains of bacteria that, when delivered to your gut's distal colon, help stimulate natural GLP-1 production. No shots, no prescription.
The results are pretty impressive; 91% of users reported reduced food cravings after six weeks*, and the higher the initial cravings, the more significant the improvement.
Why This Matters
Over the last year+, I've watched friends scramble to find GLP-1 prescriptions, hitting up sketchy compounding pharmacies, or paying astronomical prices when their insurance won't cover them. It's wild out there.But obesity isn't just about weight – it's tied to heart disease, diabetes, cancer, and even cognitive decline (some scientists are calling Alzheimer's "Type 3 diabetes"). We need better solutions that are both accessible and backed by science.
Join Our Mini-Trial
Sadly, the trial is now closed — thanks to all who participated!
What's Next?
We'll be collecting data throughout the trial and sharing the results with participants. Stay tuned for updates on how the community is progressing.
Exciting stuff ahead! As always, I'd love to hear your thoughts and experiences if you decide to participate.
Until next time, be well,
*based on a consumer survey of 274 people
This is a public episode. If you’d like to discuss this with other subscribers or get access to bonus episodes, visit www.kevinrose.com/subscribe
Transcript
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| 0:00.0 | When you think about all the probiotics are on the shelves right now, they actually represent a very |
| 0:04.5 | small fraction, less than 1% of your entire microbiome. That means there's a huge opportunity |
| 0:10.1 | to go out and create novel interventions here. So the pivotal study that we did, which is published |
| 0:14.8 | in BMJ, is a placebo-controlled, double-blinded, randomized trial, where we took people with type 2 diabetes, |
| 0:21.7 | and we showed that compared to placebo, the people who were on our formulation after 90 days |
| 0:27.5 | had a lowering of A1C by 0.6 and a lowering of blood glucose spikes by 33%. |
| 0:33.5 | That's basically how far with, yeah, if you know those numbers, that's on par with a pharmaceutical, |
| 0:38.5 | but it was this microbiome intervention that's never been made for. |
| 0:42.6 | There's another keystone strain that is also if you do a gut test at the top there, and |
| 0:48.1 | we are working diligently on that strain, which appears to play a fundamental role in how |
| 0:53.6 | your microbiome interacts with |
| 0:54.9 | your immune system. |
| 0:56.4 | Oh, wow. |
| 0:57.6 | And so we are, and it's never been brought to market before. |
| 1:05.3 | Colleen, thank you so much for joining me. |
| 1:07.6 | Thanks so much for having me. |
| 1:08.7 | Excited to be here. |
| 1:10.3 | It's been a minute since we've done a little |
| 1:12.3 | podcast together. So I'm excited to you back together. You know, I think a good place to start is |
| 1:18.1 | for those that haven't seen you on my show back in the day or they haven't seen you on Peter |
| 1:23.4 | Tia's podcast, can you give us just like the quick little, you know, three, four minute |
| 1:28.0 | version of like why your company is so different and what you're doing that's so novel |
... |
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