Bryan Johnson's $25,000 Follistatin Gene Therapy - Dissecting The Results

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Health & Fitness, Science, Education, Self-improvement

4.9 • 806 Ratings

🗓️ 1 January 2025

⏱️ 22 minutes

🔗️ Recording | iTunes | RSS

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0:00.0	Of the exotic kind of anti-aging drugs, I know that you've kept metformin in despite
0:07.5	whatever evidence has suggested that it may not be as great as it was once touted.
0:13.5	Above and beyond that, 17 alpha estradiol, which presumably has been essentially benign and unnoticeable in effects.
0:23.4	Is there anything else that you've used that you can recall as far as anti-aging?
0:29.3	I don't know.
0:30.5	Yeah.
0:31.1	Yeah.
0:31.3	The things that have the largest effect size, the full of statin gene therapy that I did,
0:36.1	many circles.
0:37.0	So they've got a plasmid
0:38.4	for a fullestin gene therapy, which in our analysis ranked number seven as the most powerful
0:43.8	lifespan extension. It was over 30% in mice. And so I did the therapy on September 10th,
0:51.7	and then two weeks later, my fullestatin levels were up 160%. So the therapy
0:57.1	did in fact have the effect. Now it's it's not editing the genes. It's just sitting inside the nucleus
1:02.9	and the production of folstatin increases. Via the gene though. Yeah. Yeah. And and so you you have the effect so you're not
1:13.4	modulating the fallistin gene expression at all yeah you're not changing the DNA got it and so
1:19.8	that that one is cool because we have been trying to figure out gene therapy for over two years
1:25.4	and we had been looking at aavVs and particular AAV9.
1:31.1	But it's challenging because if we do that gene therapy, you can't turn it off.
1:35.5	So if something goes awry, there's no kill switch.
1:38.2	And so we didn't do gene therapy.
1:39.9	Then we found this one.
	...

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