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Plain English with Derek Thompson

How AI Could Help Us Discover Miracle Drugs

Plain English with Derek Thompson

The Ringer

News Commentary, News

4.81.8K Ratings

🗓️ 13 September 2024

⏱️ 50 minutes

🧾️ Download transcript

Summary

We may be on the cusp of a revolution in medicine, thanks to tools like AlphaFold, the technology for Google DeepMind, which helps scientists predict and see the shapes of thousands of proteins. How does AlphaFold work, what difference is it actually making in science, and what kinds of mysteries could it unlock? Today’s guest is Pushmeet Kohli. He is the head of AI for science at DeepMind. We talk about proteins, why they matter, why they’re challenging, how AlphaFold could accelerate and expand the hunt for miracle drugs, and what tools like AlphaFold tell us about the mystery of the cosmos and our efforts to understand it. If you have questions, observations, or ideas for future episodes, email us at [email protected]. Host: Derek Thompson Guest: Pushmeet Kohli Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

Transcript

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0:00.0

A restaurant's best dishes tell stories.

0:04.0

Their flavors embed themselves in our memory like song lyrics or lines from a movie.

0:09.4

So much so that a little slice of a restaurant's story can become part of our own. I'm Danny Chow and this is shift meal.

0:17.0

A new video podcast from The Ringer where we're sharing a bite and chopping it up with chefs and restaurant people during their off hours.

0:24.7

Look out for episodes of shift meal on Ringer Food starting September 18th.

0:30.4

Today's episode is about the search for new miracle drugs and the future of medicine.

0:35.7

So a few years ago I was having this off-the-record conversation with a scientist who said

0:40.5

something to me that was so simple and memorable and compelling that I knew in that moment I would eventually

0:49.0

make it into some article or essay or podcast, but I never had the perfect opportunity to recapitulate his

0:55.4

observation until today.

0:58.3

He said the history of medicine has been a kind of journey to the center of the self.

1:04.0

And you can tell the multi-thousand year history of medicine

1:08.0

as a kind of three-part history.

1:11.0

In part one, which stretches back tens of thousands of years until maybe the beginning

1:17.1

of the 20th century, medicine has largely been finding miracle drugs in nature. Almost all of the earliest medicines

1:27.0

were derived from plants, animals, bacteria, fungi, leeches, for better, or worse.

1:36.0

Asperin, for example, was originally derived from a bark, white willow bark.

1:41.9

Quinine comes from a tree.

1:44.0

Morphine is derived from opium poppy.

1:47.0

Penicillin, the first truly effective antibiotic, comes from a mold.

1:51.0

Even the first vaccine in human history against smallpox comes from

1:56.2

cowpox. Hence the name vaccine from the Latin vodkaaca meaning cow.

...

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