Inside the Mind: Huberman, Sherzai, Dayspring & More on Building a Smarter, Healthier Brain | Masterclass

The Proof with Simon Hill

Simon Hill

Nutrition, Health & Fitness, Self-improvement, Education

4.9 • 2.9K Ratings

🗓️ 21 April 2025

⏱️ 146 minutes

🔗️ Recording | iTunes | RSS

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Summary

How can we protect our brain as we age and what can we do today to boost memory, focus, and resilience? In this episode of The Proof, I’ve compiled some of the most impactful conversations I’ve had with leading neuroscientists, neurologists, and brain health researchers to explore exactly that. From building better habits to slowing age-related decline, this masterclass brings you practical, science-backed strategies for optimising brain function, now and in the future. Whether your goal is sharper mental clarity, prevention of neurodegenerative disease, or simply staying sharp for the long haul, this episode is packed with insights you can use right away. You’ll learn: • How neuroplasticity allows your brain to adapt and change at any age • The role of movement and VO₂ max in protecting cognitive performance • How omega-3s and dietary fats impact brain structure and function • What APOE4 means for your risk of Alzheimer’s and why genetics aren’t destiny • The link between cardiovascular health, lipoproteins, and dementia • How the microbiome and inflammation influence brain aging • The surprising ways exercise improves brain volume and connectivity • Why creatine isn’t just for muscles and how it may enhance mental energy and mood • Actionable daily habits to reduce your risk of cognitive decline • The truth about lifestyle vs genetics when it comes to Alzheimer’s disease Featuring insights from Dr Andrew Huberman, Dr Ayesha Sherzai, Dr Dean Sherzai, Dr Thomas Dayspring, and Dr Kellyann Niotis, this episode distills cutting-edge neuroscience into clear, practical guidance for long-term cognitive health. Thank you for tuning in to today’s episode, and special thanks to the experts featured for their invaluable insights. If you found this episode helpful, please share it with someone who you think might benefit from it. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Function Health Track, optimise, and thrive with Function Health. Access 100+ lab tests – five times more than a typical physical – including ApoB and LP(a), no doctor approval needed. Get science-backed insights and track your results over time. Skip the 400,000-person waitlist at functionhealth.com/simonhill. Only available to those living in the United States. Eight Sleep Upgrade your sleep with the Pod 4 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF for $350 off at eightsleep.com/theproof. Try it risk-free for 30 days, with worldwide shipping. Momentous My go-to supplement brand for protein and creatine is Momentous. Get 20% off your first purchase by using the code LIVINGPROOF at checkout at livemomentous.com Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Follow [this link](https://eimele.com/essential-8/15660280.html.) for 20% off one-time purchases and subscriptions. Simon Hill, MSc, BSc (Hons) • Creator of theproof.com • Host of The Proof with Simon Hill • Author of The Proof is in the Plants Subscribe & Connect: • YouTube • Apple Podcasts • Spotify • Instagram: @simonhill • Twitter: @theproof • Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.

Transcript

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0:00.0	Howdy friends, Simon here. Welcome back to The Proof. Today we're diving into the incredible world
0:05.5	of your brain. Whether you're looking to boost focus, protect your memory or reduce your risk of
0:11.1	cognitive decline, this episode is for you. I've pulled together the most powerful insights
0:16.2	from some of the brightest minds in neuroscience and medicine. Dr. Andrew Huberman, Drs
0:22.3	Dean and Aisha Sherzai, Dr. Thomas Dayspring, Dr. Kelly Ann Nyotis, and a little from Me Too,
0:28.4	into one deep dive compilation that covers everything from neuroplasticity and dopamine to exercise
0:34.0	genetics, Alzheimer's prevention, and even the impact of creatine on mental performance.
0:39.1	It's the ultimate brain upgrade, backed by science and grounded in real world strategies that you can
0:44.2	apply today. Let's get into it.
1:03.4	What are some of the kind of most amazing discoveries about the nervous system, say from the last 50 to 100 years?
1:08.4	I'm assuming that technology and skills have come a long way in the field of neuroscience.
1:14.3	Are there any particular pieces of science that are up there as very critical sort of milestones or discoveries? Yes. And so at risk of giving an answer that's
1:20.9	too long, I'll kind of hit these in bullet point form because I've never been accused of being
1:24.9	concise. First of all, there's an enormous batch of textbook knowledge that is not just beautiful,
1:33.7	but truly elegant, that describes the basic functions of how we sense, perceive, feel,
1:41.6	remember, and behave. Okay, so much too much you go into all in one sweep. But for instance,
1:48.3	work in the last 50 to 100 years and mainly within the last 30 years of which I've been very
1:53.9	fortunate to be a participant. These aren't my discoveries, but I've been around to observe these
1:58.5	discoveries in various labs. My lab has made minor contributions to some of these areas.
2:02.7	But for instance, we understand how light is converted into electrical signals
2:09.1	that give rise to perception of visual images, even the recognition of faces.
2:13.7	We can point to specific areas in the brain based on the beautiful work of Nancy
	...

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