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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Modafinil Pharmacology Podcast

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 13 March 2025

⏱️ 16 minutes

🧾️ Download transcript

Summary

Modafinil (Provigil) is a CNS stimulant medication. I cover modafinil pharmacology, adverse effects, drug interactions, and much more on this podcast episode.



You should be aware that modafinil is a Schedule 4 controlled substance so it does carry a risk of dependence and addiction.



Modafinil can cause CYP3A4 induction and lead to lowering the concentrations of many medications. This includes antiepileptic agents and oral contraceptives.



The most common adverse effects of modafinil include ramping up the body and causing symptoms such as anxiety and insomnia.



Cardiovascular changes are a risk with modafinil as this medication can contribute to hypertension and tachycardia.

Transcript

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0:00.0

Hey, all, welcome back to the Real Life Pharmacology podcast. I am back to focusing on specific medications here for a little bit.

0:08.9

So if you have any request, suggestions, I can definitely take a look at and see if I can get them on the list here to cover.

0:16.8

So with that said, always go to real-life pharmacology.com.

0:21.3

Get your free study guide, just 31-page PDF on the top 200 drugs.

0:26.1

Great no-brainer to have that refresher, or if you're in pharmacology,

0:30.4

classes in college, or whatever the case may be,

0:33.7

definitely may be helpful there for you as well, as I include some of the most important things you see in practice,

0:39.7

as well as that show up on board exams.

0:45.0

All right, so the medication I want to cover today is modafinil.

0:50.8

Brand name of this medication is ProVigil.

0:53.8

This is classified as a central nervous system stimulant.

0:59.6

With that said, kind of that general classification also includes medications like amphetamines, for example.

1:09.9

So medications that can be used for ADHD and things of that nature.

1:15.2

In kind of a generalized scale, it's not always perfect to do it this way because a lot of

1:20.7

its dose dependence as well.

1:22.7

But generally, I would classify medication like modafinil, maybe a little less potent of a CNS

1:30.3

stimulant compared to, you know, some of the meds for ADHD, for example, like adderol

1:37.7

and things of that nature, methylphenidates.

1:40.0

So with that said, again, that's a relative scale based upon dose and other things included there.

1:47.1

But that's kind of my initial thought process when I think about this medication here a little bit.

1:54.0

So modafinil from a mechanism of action standpoints, it increases dopamine, but it typically isn't as potent as the amphetamines.

2:07.0

It does that by essentially blocking dopamine transporters in the brain, so it increases that dopamine

...

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