Prasugrel Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5 • 716 Ratings

🗓️ 31 October 2019

⏱️ 11 minutes

🔗️ Recording | iTunes | RSS

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Summary

Prasugrel is a P2Y12 inhibitor that is used in the setting of ACS.

Be aware of patients who may be taking over the counter medications that can increase their bleed risk while taking prasugrel.

Prasugrel is on the Beers list and in general, should be avoided in most situations for patients who are 75 years of age or older.

Morphine has the potential to impact antiplatelet agents like prasugrel and make them less effective. Be sure this is clinically considered prior to using morphine with prasugrel.

Transcript

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0:00.0	Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, Eric Christensen.
0:06.3	And you can track us down at real lifepharmacology.com. Definitely go take advantage, sign up,
0:13.2	and snag your free 31 page PDF for the top 200 drugs where I lay out really real world important pearls with each of those
0:24.0	drugs in the top 200.
0:25.7	So a great little resource there.
0:27.7	If you're studying for any board exams or anything, pharmacology classes, anything coming
0:33.4	up there.
0:34.1	So go snag that at real life pharmacology.com.
0:38.2	All right. So we're going to get into it today covering Prasagrel.
0:43.2	Brand name of this medication is effiant.
0:46.4	And this medication is classified broadly as an anti-platelet agent.
0:52.8	A little bit more narrowly. It is a P2Y-12 inhibitor.
0:58.9	So P2Y-12 is actually part of ADP receptors,
1:05.4	and those receptors are found on platelets.
1:09.1	So to have its anti-platelet activity,
1:12.6	the drug binds to that P2.Y12 part of the ADP receptors,
1:17.9	and ultimately this inhibits the function of the platelet
1:22.9	to be activated and to bind and stick to other platelets.
1:29.1	Okay.
1:29.5	And what that's going to do is play into the fact that this is going to inhibit
1:36.4	platelet aggregation and help prevent blockages within vessels.
1:42.3	So the primary indication here for Prasigrel, you'll see it used in
	...

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