4.9 β’ 806 Ratings
ποΈ 13 June 2017
β±οΈ 31 minutes
ποΈ Recording | iTunes | RSS
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0:01.0 | So, guys, Derek, more plates, more dates.com. |
0:03.4 | Today we're going to be talking about S23, which is arguably one of the most powerful |
0:10.2 | SARMs in pre-clinical development right now. |
0:14.0 | This is going to be the most comprehensive video on the entire internet about S23. |
0:17.8 | I assure you that, as well as posts on the entire internet as well. |
0:21.1 | If you want to check out the article version, which I posted back a couple of years ago and has been |
0:26.6 | updated with the, to reflect the most current and up to date information. So without further ado, |
0:32.1 | let's get into it. So S23 is undoubtedly one of the strongest SARMs in development right now. |
0:39.2 | It has an extremely high binding affinity. |
0:41.2 | It's very suppressive. |
0:42.7 | And it's a very potent muscle builder with a high level of tissue selectivity relative to anabolic endogenic steroids. |
0:50.9 | Or at least most of them. |
0:52.8 | So what is it exactly? It's a selective androgen receptor modulator |
0:57.0 | SARM currently under development for potential use as a male hormonal contraceptive it is still in the |
1:03.4 | pre-clinical stage of development meaning it has only been tested on animals not humans as 23 exhibits |
1:10.1 | a high affinity for the androgen receptor with tissue |
1:13.3 | selective anabolic effects in muscle and bone with relatively less stimulation in the prostate, |
1:19.3 | semenal vesicles, and other androgen affected tissues. S23 was created by modifying the structure |
1:26.0 | of an older and less efficacious sarm called C6 |
1:30.2 | by changing the perinitro group of C6 to a cyanideconetic studies showed that C6 is 76% orally |
1:39.4 | bioavailable and by swapping the perinitro group for a cyanide group, S23 is able to achieve 96% oral bioavailability. |
1:50.3 | The closer a SARM is to a 100% bioavailability, the closer it is to complete absorption after oral dosing. |
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