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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Sertraline Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 6 August 2020

⏱️ 16 minutes

🧾️ Download transcript

Summary

Sertraline is an SSRI. It has the highest potential to cause diarrhea of any SSRI.



Sertraline is often called "Squirtraline" because of its potential to cause diarrhea.



Sertraline has a much shorter half-life than fluoxetine. I discuss why that may be important in this podcast episode.



I discuss the role of serotonin in platelet aggregation and how sertraline may affect this.

Transcript

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0:00.0

Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist Eric Christensen,

0:06.2

and I thank you so much for listening today. If you enjoyed the podcast, of course, go to

0:11.7

real life Pharmacology.com. You can sign up there and also snag a free 31-page PDF study guide

0:20.6

on the top 200 drugs.

0:23.0

So go snag that for free and we'll also get you email updates when we've got new releases

0:29.4

of the podcast and other content as well.

0:32.8

So definitely a no-brainer to go grab that resource for free there so today I'm going to

0:40.3

cover searcherling brand name of this medication is Zoloft and I've done a couple of SSRIs I

0:50.2

believe so far and with that there's subtleties between the SSRIs. And I wanted to make sure that those

0:59.4

are all pointed out because they are important and there is different reasons for selecting

1:07.4

different SSRIs and or different things to look out for as we use these

1:13.0

medications.

1:14.2

So mechanistically, it's not going to be different from any of the SSRIs if you've

1:20.2

listened to previous podcasts on drugs like satalopram.

1:25.0

So those presynaptic cells or neuronal cells release that serotonin,

1:32.2

and they will also re-uptake, basically take back in that serotonin out of the synapse

1:39.9

and essentially stop that serotonergic activity.

1:50.9

SSRIs block or reduce the amount of that re-uptake that happens.

1:58.3

So more serotonin stays in the synapse and gives you physiological responses and hopefully helps manage, treat indications like depression, anxiety disorders,

2:07.0

PTSD, OCD, in the way the medication works there.

2:14.0

All right, so one thing I really wanted to point out was dosing.

2:18.8

It's just common sense.

...

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