Welcome to Breakthroughs with Pfizer-UK, the podcast where Pfizer invites experts from across

the pharmaceutical industry to discuss the most pressing healthcare topics.

Approximately 5% of the red disease is estimated to be about 7,000 that exist.

Only 5% of them have treatments.

Because of the really small patient numbers, you can't have your giant trials that give

shoes statistical power.

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Why would a normally developing girl stop walking?

What causes a middle-aged person to lose their sense of balance?

Dr. Huda Zagbi has devoted her career to unraveling these puzzles.

She shares the Kavli Prize with Jean Louise Mandel, Harry Orr and Christopher Walsh

for discovering the genetic pathways behind serious brain disorders.

Scientific American custom media, in partnership with the Kavli Prize,

spoke with Huda to learn more about her research.

The Kavli Prize is a prestigious honor on its own, but the award holds a special place in Dr.

Huda Zagbi's heart. Because it recognizes work that I have so cherished it is work with my

longtime collaborator, Harry Orr. And I so cherish the work as well as our relationship over the

years. So to me, this was the sweetest way to recognize that work.

Huda and Professor Harry Orr both received the Kavli Prize this year for research that has

been intertwined for decades. Our collaboration has outlasted most American marriages.

It all started when Huda was at the very beginning of her career.

She was trying to unravel the genetic cause of a disorder that affected the balance and speech

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