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The Most Effective GH Dose For Fat Loss Per Administration

More Plates More Dates

More Plates More Dates

Health & Fitness, Science, Education, Self-improvement

4.9806 Ratings

🗓️ 13 February 2020

⏱️ 3 minutes

🧾️ Download transcript

Summary

https://youtu.be/i7erwHTh8OM Contrary to popular belief, more is not better when it comes to exogenous GH use for fat loss. There is a ceiling on lipolysis, and the highest GH dose for maximizing fat loss per administration is much lower than most people think.  As you can see here in the following study assessing the pharmacokinetics and acute lipolytic actions of GH, there were significant dose-response effects when comparing the incremental area under the curve of both free fatty acids and blood 3-hydroxy-butyrate following 0, 1, and 3 mcg/kg GH, whereas there were no differences between the responses following 3 and 6 mcg/kg GH [R]. These dosages were administered intravenously.  1 mg of Somatropin corresponds to 3 IU (International Units) of Somatropin [R]. So, this means that for someone who weighs 100 kg, lipolysis is maxed out at about 300 mcg of Somatropin, which is 0.9 IU’s of pharma grade GH IV.  We need to math out the corresponding subcutaneous dose based on the bioavailability and bioactivity comparison data we have on humans administered HGH.  Obviously IV dosages are not representative of what dosages would be via the far more realistic and tolerable method of administration (subcutaneous).  In one study, the mean estimated availability of subcutaneous injected HGH was shown to be 63% of that of HGH administered I.V. after correcting for differences in the GH dose [R]. Another study found the availability of subcutaneous injected HGH to be about 70% of that of HGH administered I.V. [R]. So, for a 100 kg man, fat loss benefits would be maxed out around 1.35 IU of GH per administration subcutaneously.  There is a refractory period cells need before another pulse of exogenous GH can even be useful in a lipolysis context, which I will delve into further in a future article.

Transcript

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0:00.0

For I use at once as a complete waste.

0:02.8

And one thing I should say is I 100% agree with lipolis being a huge factor to your GH being

0:10.6

useful or not in a lypolytic context.

0:13.2

Like if you're fasted, the effects GH is going to have on fat mobilization in regards to

0:19.5

what you're actually burning during your cardio session or your training session if you're fasted versus not fasted it definitely matters like that he's definitely correct on however as far as the amount at once there's a ceiling on lipolysis which he's not accounting for here and it's much lower than most people think and this is why a lot of people are putting unnecessary stress on themselves and wasting money and taking too much GH.

0:39.6

As you can see here in the following study, assessing the pharmacokinetics and acute, lipolytic actions of GH.

0:46.6

There were significant dose response effects when comparing the incremental area under the curve of both free fatty acids and blood three hydroxybutyrate following 0,1, and

0:56.6

three micrograms per kilogram of GH administration, whereas there were no differences between

1:03.4

the responses following three and six micrograms per kilogram of GH.

1:08.4

So these dosages were administered intravenous. So as far as what

1:12.6

milligrams equate to in international units, one milligram of somatropin corresponds to three

1:18.0

IU international units of somatropin. You can see this reinforced in the Nordotropin product information

1:25.9

pamphlet or their, you know, product information form that they include.

1:31.4

So this means that for somebody who weighs 100 kilograms, for example,

1:35.9

lipolisus is maxed out at about 300 micrograms of somatropin, which is 0.9.

1:42.7

I use of pharma grade GHIV. So we need to math out the corresponding

1:48.0

subcutaneous dose based on bioavailability and bioactivity comparison data that we have on

1:54.2

humans administered HGH because obviously IV dosages are not representative of, you know, what dosages would be via a far more

2:04.5

realistic and tolerable method of administration, which is the subcutaneous route.

2:10.7

So in one study, the mean estimated availability of subcutaneous injected HGH was shown to be

2:16.5

63% of HGH administered IV after correcting

2:21.4

for the differences in the GH dose. Another study found the availability of subcutaneous injected

...

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