Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

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Health & Fitness, Science, Education, Self-improvement

4.9 • 806 Ratings

🗓️ 13 February 2020

⏱️ 3 minutes

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Summary

At supraphysiological dosages, taking GH before going to sleep makes sense because there is a negative feedback loop on the growth hormone (GH)/insulin-like growth factor I (IGF-1) axis. In this study, IGF-1 was constantly infused, and the effect on endogenous GH secretion was assessed [R]. Overall, GH concentrations were suppressed during the rhIGF-I infusion by 85±3%, mainly by attenuating spontaneous GH pulse amplitude (77±4% suppression). The apparent GH pulse frequency was attenuated from 7.8±0.9 to 4.7±0.6 pulses/24h (P= 0.006). IGF-1 is the primary feedback, and the mechanism is similar to what you see with the HPTA axis. When there is enough Testosterone and Estrogen, your body has this mechanism in place to prevent you from making more. The same thing happens with exogenous GH use. When you administer exogenous GH, IGF-1 elevates. When your body recognizes that IGF-1 is elevated, it starts to suppress GH pulse amplitude in a dose dependent manner. If you are using supraphysiological amounts of GH for bodybuilding purposes, you can assume that your natural secretion is greatly inhibited during sleep as this negative feedback loop will prevent your body from secreting GH in your sleep like it normally would. When endogenous GH production is suppressed, administering exogenous GH at times that lipolysis or muscle growth can be optimized is the most logical approach to injection timing. https://youtu.be/8j9MGfQPeXg If fat loss is the goal, then taking GH in a fasted state prior to fasted cardio would be ideal. There is a ceiling on how much GH is needed to maximize lipolysis, so if your dosage exceeds 2 IU per day, then I would advise splitting up that dose into two (or more if needed) different periods of the day with as much time between them as possible. If muscle growth is the goal, GH should still be administered in a pulsatile fashion to mimic endogenous secretions. Topped out stimulation of autocrine IGF-1 in skeletal muscle can be achieved with fairly low dosages of exogenous GH, and administering a higher dose above and beyond that may just be a waste. This is why it would be wise to split up your daily GH dose into multiple administrations if you are using supraphysiological dosages.

Transcript

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0:00.0	In a super physiological context, if we're talking about bodybuilding, then yeah, I agree that pre-bed, one of the dosages pre-bed makes sense.
0:07.7	The reason being there's a negative feedback loop with GH and IGF-1.
0:12.1	So I'm going to post a study here called negative feedback regulation of pulsatile growth hormone secretion by insulin-like growth factor 1 involvement of hypothalamic somatostatin.
0:22.5	So in this study, IGF-1 was constantly infused and the effect on endogenous GH secretion was
0:28.9	assessed.
0:29.5	Overall, GH concentrations were suppressed during the IGF-1 infusion by 85%, mainly by attenuating spontaneous GH pulse of amplitude, 77% suppression.
0:42.9	The apparent GH pulse frequency was attenuated from 7.8 to 4.7 pulses per 24 hours.
0:49.4	So there's a negative feedback loop on the growth hormone IGF1 axis. So it's similar to how, you know,
0:57.8	the HPTA works when you have, you know, elevated testosterone and estrogen levels or your body
1:03.0	senses that you have a sufficient amount. It's going to prevent you from making more.
1:07.8	And this is, you know, sort of how it regulates itself. So IGF1 is the
1:11.4	primary feedback in this loop for the GH IGF1 axis and it acts in a similar mechanism. So the same
1:18.7	thing happens when you administer exogenous GH. When you administer GH, your IGF1 levels increase,
1:24.4	obviously. And then the result of that is your body has this feedback loop in place that recognizes IGF1
1:30.3	is elevated, therefore it doesn't need to produce as much GH.
1:33.3	So when your body recognizes that IGF1 is elevated, it's going to start suppressing
1:37.3	GH pulse amplitude in a dose-dependent manner.
1:40.3	So if you're using superphysiological amounts of GH for bodybuilding purposes, you can assume that your natural secretion is greatly
1:46.8	inhibited during sleep as the negative feedback loop will prevent your body from secreting GH in your sleep like it normally would.
1:54.7	So this is where it actually makes sense to use, you know, part of your daily dose pre-bed because that secretion, that pulse you would get during sleep, you're no longer getting.
2:05.2	So, you know, replacing it in that time frame where, you know, recovery is the most critical.
2:13.2	It obviously makes sense.
	...

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