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The Journal.

The New Hit Depression Treatment? A Ketamine-Derived Nasal Spray

The Journal.

The Wall Street Journal

Daily News, Business News, News

4.25.3K Ratings

🗓️ 21 March 2025

⏱️ 21 minutes

🧾️ Download transcript

Summary

After it was approved in 2019, Spravato, a depression treatment derived from the club drug ketamine, was looking like a dud. But recently it has taken off, and it surpassed $1 billion in annual sales last year for its maker, Johnson and Johnson. Further Listening: -A Lawyer Says He Doesn't Need Help for Psychosis. His Family Disagrees.  -America's Maternal Mental Health Crisis  Further Reading: -J&J’s Ketamine-Derived Drug Is Taking Off  -Big Pharma Walked Away From Mental Health. Why Some Are Coming Back.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

A quick heads up before we get started.

0:02.6

This episode mentions suicide and discusses depression.

0:06.0

Please listen with care.

0:13.4

So just to start us off, could you introduce yourself, your name, your age, what you do?

0:18.5

My name is Sean Fury. I'm a writer in Fort Worth, Texas. I'm 36 years

0:22.5

old. And I'm seeing some, like a very interesting background there for you. You've got a poster.

0:28.9

You've got, is that creature from the Black Lagoon? It is. That's my favorite. Sean loves

0:34.3

movies, but he doesn't just love to watch them. He makes them too.

0:39.0

Horrors might go to. We just finished the first leg of a shoot of a horror thriller. It's a vampire film.

0:46.1

Why did you want to make this film?

0:48.0

You know, to kind of work through my own issues with that depression and anxiety, PTSD.

1:00.8

And I chose a vampire type story because I feel like there are times where I felt really low where I just feel like I'm sucking the life out of my family, my wife.

1:04.9

Yeah.

1:05.5

So I decided to make that literal and explore it through a vampire film.

1:12.1

Sean says depression has been part of his life for as long as he can remember. At times, he

1:17.3

says it's been debilitating. There are days where my wife has to physically help me out of bed.

1:23.1

I just can't get up. I can't really bear to face the day. What kind of treatments have you tried over time?

1:30.5

Pretty much anything that came onto the market, I tried. And it is hard because you start taking

1:38.0

it and you don't notice if it works or not for a couple weeks. And then by that point,

1:43.9

you have to kind of wane yourself off of it to try something new.

1:47.6

And in the meantime, those antidepressants can have several side effects on your body,

1:52.1

which are frustrating as well.

...

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