Top 10 SSRI Drug Interactions Podcast
Real Life Pharmacology - Pharmacology Education for Health Care Professionals
Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist
5 • 716 Ratings
🗓️ 11 April 2024
⏱️ 16 minutes
🧾️ Download transcript
Summary
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In this podcast episode, I discuss how to navigate SSRI drug interactions and identify some of the most common medications that have additive serotonergic activity.
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Paroxetine and fluoxetine inhibit CYP2D6 I discuss how this can affect the benefits of tamoxifen therapy.
Fluvoxamine is a nasty medication with regard to the number of and significance of drug interactions. I outline important fluvoxamine interactions in this podcast episode.
Transcript
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| 0:00.0 | Hey, healthcare friends. Do you dread doing your notes every day? Do you feel like you can never get ahead of charting? |
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| 0:48.5 | freed AI do the rest. Welcome back to the Real Life Pharmacology podcast, everybody. Today I'm going to cover some SSRI drug |
| 1:00.6 | interactions. So there's plenty to pull from. I've got some specifics on specific SSRIs that have |
| 1:08.8 | some interactions as well as kind of some general interactions I wanted to |
| 1:11.8 | cover. So we're going to go through that here. So number one, the biggest thing that comes up in |
| 1:18.2 | practice regarding SSRIs and serotonergic agents is the risk for serotonin syndrome. Now serotonin |
| 1:26.7 | syndrome, it's a very rare situation. |
| 1:31.2 | You can get hyperthermia. You can get some elevations in cardiac function, such as tachycardia, |
| 1:38.5 | for example. So this is a very, very significant drug interaction risk, but again, it's not incredibly common, but I think it is important to pay attention to. |
| 1:52.9 | So SSRIs can cause this on their own, obviously, but we can increase the risk of this happening by adding other medications |
| 2:03.0 | to it. |
| 2:03.8 | So I've got a list of drugs that have serotonergic activity that you definitely need to look |
| 2:10.3 | out for and pay attention to. |
| 2:11.9 | So lenaesolid is one that definitely comes to mind. |
| 2:26.3 | It is an antibiotic for infection, most commonly used for MRSA, maybe used for VRE as well. And this drug has MAOI activity, and it is recommended to avoid the use of lenaesolid with SSRIs. I also want to say |
| 2:39.9 | MAOIs themselves, so these are older antidepressant type agents. In clinical practice, I don't see |
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