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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Top 200 Drugs – Medications 51-55

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5 β€’ 716 Ratings

πŸ—“οΈ 15 August 2024

⏱️ 17 minutes

🧾️ Download transcript

Summary

On this episode of the Real Life Pharmacology podcast, I cover medications 51-55. They are eszopiclone, celecoxib, estrogen, moxifloxacin, and donepezil.



Eszopiclone is a "Z" drug used for insomnia. Its adverse effect profile is very similar to benzodiazepines.



Celecoxib is a COX-2 Inhibitor used for pain and inflammation. I discuss how this medication differs from traditional NSAIDs.



Estrogen therapy is used for menopausal symptoms but carries a risk of cancer and blood clots.



Moxifloxacin is a quinolone antibiotic. Binding drug interactions, boxed warnings, and QTc prolongation are potential concerns.



Donepezil is a medication used for dementia. I discuss its mechanism of action and common adverse effects.

Transcript

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0:00.0

All right, so getting into the medications today, drug at number 51, the brand name is Lunesta.

0:07.5

Generic name is Azopaclone.

0:11.6

Its mechanism of action is it binds to and potentiates the effect of gamma receptors leading to a sedative type effect.

0:20.2

So, as you can imagine, this medication is

0:22.9

classified as a sleeper or a sedative type agent. Again, falls under the classification of a

0:31.9

Z drug because the generic name has a Z in it and it's for sleep. So that's a good kind of classification to remember if you're being tested on that.

0:41.4

And mechanistically, it works very similar to benzodiazepines.

0:47.1

So as you could expect, we are going to have a very, very similar adverse effect profile.

0:54.9

So dizziness, confusion, obviously sedation, that's generally what we're trying to do there.

1:02.8

Increased risk for falls, particularly in the elderly.

1:07.2

Also, you know, associated with most of the sleeping medications, we can have some rare sleep-type

1:14.4

side effects.

1:15.1

And the Z-drugs are specifically notorious for this.

1:18.9

Sleep-walking, sleep-eating, kind of these unique and abnormal sleeping-type behaviors.

1:27.5

In addition to that, vivid or bad dreams are possible.

1:32.6

This is definitely something I've heard patients report.

1:36.9

There is a risk of addiction and dependence with these agents.

1:41.4

So they are a controlled substance and they are scheduled for there.

1:46.8

So with Lunesta specifically, I keep an eye out for patients who are using this long term.

1:55.6

Obviously, like to try to get them off of a controlled substance long term, if at all possible.

2:02.3

Do your best limit dose, so minimize that risk for falls and confusion and other kind of

2:08.6

collateral damage. And then, of course, making sure that we're tapering periodically or

...

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