Top 200 Drugs Podcast – Drugs 21-25

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5 • 716 Ratings

🗓️ 4 July 2024

⏱️ 14 minutes

🔗️ Recording | iTunes | RSS

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Summary

Lamotrigine is an antiseizure medication and also may be used for bipolar disorder. A rash is a major side effect to remember with this medication.

Valganciclovir is an antiviral medication that can be used to prevent cytomegalovirus (CMV) in patients with a suppressed immune system.

Fluconazole is an azole antifungal that can be used to treat candidiasis, blastomycosis, and tinea infections. Drug interactions, QTc prolongation, and hepatotoxicity are potential risks.

Atenolol is a beta-blocker used to treat atrial fibrillation and hypertension. It is relatively selective for beta-1 receptors meaning that it doesn't affect the lungs as much as non-selective agents.

Montelukast is a medication that blocks the actions of leukotrienes. This can be beneficial for the management of allergies and asthma.

Transcript

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0:00.0	Hey all, welcome back to the real-life pharmacology podcast. I'm your host pharmacist, Eric Christensen.
0:05.9	Thank you so much for listening today. We are going to be continuing on with the top 200 drugs,
0:12.9	and I am on drugs number 21 through 25 today. And as a reminder, head on over to real-life pharmacology.com. Get your free PDF on the top
0:25.7	200 drugs. Great study guide, great refresher. Lots of good clinical pearls, things you're going to
0:32.3	see in practice, as well as things that show up on board exams. So definitely a no-brainer.
0:36.7	Simply an email. We'll get
0:38.1	you access to that. And then we've got updates for you as well when we've got new podcast episodes
0:43.7	and other content available. All right. So number 21 is Valgang Cyclevere. Brand name of
0:52.9	this medication is Valcite.
0:56.1	And mechanistically, what this medication does is essentially blocks viral DNA synthesis.
1:05.5	It's actually a pro-drug.
1:07.6	Val-gang syclover is converted to Gansiclevare.
1:13.3	And probably the most common use I've seen this used for is CMV, prevention, prophylaxis, treatment.
1:23.5	So CMV stands for cytomyglovirus, and it is going to be most commonly associated with patients who are immunosuppressed.
1:33.3	So transplant patients, HIV-AIDS patients, they're at higher risk for this infection than patients who have a normally functioning immune system.
1:49.5	So adverse effects, boxed warnings, there are a bunch of boxed warnings that are associated with
1:56.5	valganiclyivir.
1:59.7	Hematologic toxicity, so that can be low white blood so cowl and low platelets, anemia.
2:06.3	It can actually impair fertility, so increase the potential for patients not being able to get
2:13.7	pregnant, things of that nature.
2:16.1	Fetal toxicity, birth defects can happen with this
2:19.7	medication as well. That is another boxed warning. And then there's cancer-associated risks as well
	...

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