Top 200 Drugs Podcast – Medications 136-140

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5 • 716 Ratings

🗓️ 12 December 2024

⏱️ 21 minutes

🔗️ Recording | iTunes | RSS

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Summary

On this episode, I cover cinacalcet, solifenacin, haloperidol, hydrocortisone (focused on topical), and insulin NPH.

Cinacalcet is a calcimimetic medication that can be helpful in hyperparathyroidism and useful for managing hypercalcemia.

Solifenacin is a urinary antimuscarinic used primarily for overactive bladder. It is an anticholinergic medication that can be problematic in our geriatric patients.

Haloperidol is a first generation antipsychotic that has a high incidence of EPS relative to many newer antipsychotics.

Hydrocotorisone is one of the most common topical corticosteroids that can be used to reduce inflammation and redness from skin reactions.

Insulin NPH is an intermediate acting insulin that is meant to be given on a routine basis. It has fallen out of favor since insulin glargine and other long acting agents allow for few injections and more stable kinetics.

Transcript

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0:00.0	Hey, all, welcome back to the real-life pharmacology podcast. I'm your host, pharmacist, Derek Christensen.
0:05.2	Thank you so much for listening today. Continuing on with the top 200 drugs, we've got number 136,
0:12.1	and that is Cinnacelset. Brand name of this medication is Sensipar. This is what's classified as a
0:19.1	calcimimimetic medication.
0:21.9	Ultimately, what we're trying to do with this medication is treat primary hyperparathyroidism,
0:29.2	secondary hyperthyroidism.
0:31.2	I would say more typically secondary hyperthyroidism.
0:36.5	But elevations in calcium can occur from this disease state,
0:42.4	particularly in patients with KD, and this medication can treat those higher calcium levels.
0:51.7	And mechanistically, it does this by increasing sensitivity of calcium receptors,
0:56.4	and ultimately this is going to cause that serum calcium to go down as that calcium is
1:05.2	uptaken into the cells. Okay, so that's ultimately going to reduce calcium and going to reduce PTH there as well.
1:14.7	Some warnings, some things to pay attention to.
1:18.3	There have been arrhythmias associated basically with the drug working too well if we're not
1:25.2	paying attention to lab work.
1:27.4	So if that calcium level drops too far, we can run into a situation of causing life-threatening
1:33.7	arrhythmias as well as life-threatening hypokalcemia associated with that.
1:40.1	So adverse effect profile, as you could imagine, just alluded to that, we can drop that calcium
1:45.0	too far, cause low calcium levels.
1:48.5	Dropping blood pressure can happen with this medication as well.
1:53.5	And GI bleed has been associated with this medication as well.
1:57.8	So think of it along the lines of, you know, inseds, for example.
	...

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