Why you should test ApoB | Dan Soffer, Md

The Proof with Simon Hill

Simon Hill

Nutrition, Health & Fitness, Self-improvement, Education

4.9 • 2.9K Ratings

🗓️ 11 November 2024

⏱️ 170 minutes

🔗️ Recording | iTunes | RSS

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Summary

Episode #339. Are you getting the full picture of your heart health? Learn why ApoB is the test you shouldn't skip. In this episode, I sit down with Dr Daniel Soffer, a preventive cardiologist and lipidologist, to break down the importance of ApoB testing for cardiovascular risk assessment. You'll learn why ApoB provides more comprehensive insights than LDL cholesterol alone, who can benefit most from this test, and how it fits into preventive cardiology. Dr Soffer shares practical advice for assessing cardiovascular disease risk, discusses the implications of diet and genetics on heart health, and explores case studies to help you understand when and why ApoB testing is crucial. Specifically, we discuss: Introduction (00:00) Insight into Preventive Cardiology and Lipidology (01:38) Understanding Lipoproteins and Their Role in Cardiovascular Disease (06:40) Techniques for Lipoprotein Testing and Measurement (11:33) Exploring Atherosclerosis and Lipoprotein Retention Hypothesis (31:18) Epidemiological Changes in Health and Cardiovascular Profiles (55:06) Concerns about the Keto Diet and Elevated ApoB Levels (58:26) Approaches to Managing Elevated LDL Levels Clinically (01:01:13) The Role of Evidence-Based Medicine in Cardiovascular Guidelines (01:07:15) Comparing ApoB and LDL Cholesterol in Cardiovascular Risk (01:14:36) Understanding Discordance in Lipid Measurements (01:18:36) Advanced Imaging Techniques for Risk Assessment (01:25:50) Guidelines and Considerations for Statin Therapy (01:44:30) Coronary Artery Calcium Score, Stroke Risks, and Carotid Ultrasound (01:54:03) Dietary Interventions and Carotid Intima-Media Thickness (IMT) (01:59:22) Case Study: Family History’s Role in Cardiovascular Risk (02:05:05) Overview of Statins, PCSK9 Inhibitors, and Other Lipid-Lowering Therapies (02:12:24) Aspirin Therapy and Imaging in Cardiovascular Health (02:26:06) Setting Treatment Thresholds Based on ApoB Levels (02:39:57) Closing Thoughts on Cardiovascular Risk and ApoB (02:44:16) This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 20% off your first order and subscriptions. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Momentous My go-to supplement brand for protein and creatine is Momentous. Use code LIVINGPROOF at checkout for 25% off and receive a free gift of 5 nights of their best-selling Sleep packs for orders over $75 at at livemomentous.com. Pique Tea Pique’s Black Friday special is HERE. For a limited time, get a Chai tea FREE with your qualifying purchase at piquelife.com/simon. This is the only time you can get your hands on their Chai. Act fast; this limited-time offering is sure to sell out! The offer ends November 16th. Eight Sleep Upgrade your sleep with the Pod 4 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF for $350 off at eightsleep.com/theproof. Try it risk-free for 30 days, with worldwide shipping. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook

Transcript

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0:00.0	Dan, got that prescription pad handy?
0:03.1	Yes.
0:05.4	I get the feeling we may need that by the end of this conversation, but let's see how we go.
0:11.4	Thank you so much for making the time to join us.
0:14.9	You're out here in L.A. for a conference.
0:16.9	Yes, that's right, Simon.
0:18.0	It's my pleasure.
0:18.9	It really is my pleasure to sit with you and talk to you. I listen to your podcast, so I've been looking forward to meeting with you.
0:27.9	I think it was Carol Kirkpatrick and Kevin Mackey, who were on the show a few weeks ago that introduced us. Or maybe it was Thomas Day Spring. I couldn't recall.
0:35.5	I think it might have been Tom.
0:36.4	That was Tom. Okay. So thank you, thank you, Tom for that.
0:40.6	I was really interested in a recent clinical consensus paper that you wrote on APOB with Carol.
0:48.8	Was Carol on that paper too?
0:49.9	Carol and Kevin.
0:50.6	Carol and Kevin.
0:51.5	There we go.
0:52.0	So the three of you and a team from the NLA
0:54.9	National Lipid Association wrote this really informative paper on the role of APOB in the
1:02.7	management of cardiovascular disease risk. And APOB has been something that we've covered on this show,
1:09.7	of course, with Tom in a lot of detail, and in other
1:13.5	episodes, but we've never had a kind of dedicated episode that is sort of aimed at helping
1:21.1	the individual who's listening, who's just thinking, you know, how do I assess and reduce
	...

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