4.8 • 995 Ratings
🗓️ 25 November 2024
⏱️ 25 minutes
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0:00.0 | Hi, Bab, it's Matt here and welcome back to the podcast. |
0:07.6 | Today is another one of those episodes of Hot Off the Press. |
0:12.3 | This is a really interesting study. |
0:15.0 | It looked at the interaction between sleep, a new class of sleeping pills, |
0:26.2 | your metabolism and as a consequence, weight management. |
0:34.1 | And more specifically, we'll be looking at a class of insomnia drugs known as the DORAs, |
0:39.6 | that is spelled capital D-O-R-A small S. |
0:46.1 | And it stands for dual-orexin receptor antagonists. |
0:49.4 | Don't worry, I'll unpack it and I'll explain it. |
0:51.2 | But it is a class of drugs. |
1:00.2 | And currently in the United States, at least, there are three FDA-approved Dora's drugs, and we will speak about one of them today. |
1:06.1 | And specifically, we won't just talk about what the drug is and how it works for insomnia. |
1:15.8 | We'll also speak about whether or not it may help you burn fat while you sleep and yet still preserve some muscle. |
1:21.9 | Right from the get-go, I think it's crucial to approach this topic with caution. |
1:29.5 | The potential benefit of these Dora's drugs, and specifically the one that we'll speak about today, which is called Belsomra, or its pharmacological name, is called suvo-rexant. But the potential for these drugs, |
1:38.3 | specifically Belsomra, or suvorexent, for fat-burning during sleep, these are based on just some preliminary research that we'll |
1:47.2 | discuss. And as with all first studies, it is a fantastic potential outlet for further research, |
1:55.4 | but it is just a small study and I want to couch that right up front. Before we dive into the actual study itself |
2:03.2 | and the findings, let's understand what these Dora's drugs do. And I said that the term describes |
2:11.4 | what we call the dualorexin receptor antagonists or the antagonist drugs. What is orexin? Well, orexin, which is also known by a |
2:25.8 | different name called hypochretin, and by the way, they are interchangeable. It's the same chemical. |
2:32.1 | And more specifically, it's what we call a neuropeptide. And it's produced |
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