Ask Me Anything Part 13: Circadian Rhythms, Biphasic Sleep, Gut Health, and Animal Sleep Secrets

The Matt Walker Podcast

Dr. Matt Walker

Medicine, Science, Social Sciences, Health & Fitness

4.8 • 995 Ratings

🗓️ 2 December 2024

⏱️ 56 minutes

🔗️ Recording | iTunes | RSS

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Summary

Matt and Eti’s latest AMA episode begins with an exploration of the fascinating relationship between circadian rhythms and medication effectiveness. Discover how this internal 24-hour clock influences drug absorption, distribution, metabolism, and excretion, impacting treatment outcomes. The episode then delves into chronotherapy, revealing how timing can optimize medication efficacy and minimize side effects for conditions like high cholesterol and high blood pressure. Together, our hos...

Transcript

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0:00.0	Hi there, it's Matt here and welcome back to the podcast and welcome back to another of the
0:09.6	AMA episodes, Ask Me Anything.
0:13.1	As always, I am joined by my partner in Sleep and Dream Crime, which is Dr. Eti Ben-Simon.
0:24.3	Eti, welcome back.
0:26.2	Thank you.
0:26.8	It's great to be here.
0:28.0	I hope we've got lots of questions.
0:30.2	Why don't we just dive in?
0:32.1	We have great questions.
0:34.0	The first one is about circadian rhythms.
0:37.4	Someone is asking, how do circadian rhythms change the effects of medications I may be taking?
0:43.7	Oh, wow. Great question. Sucadian rhythms, we've done multiple episodes on this. So I think there are maybe a collection of different ways that the circadian rhythm does alter medication effects.
0:56.3	The first is the absorption.
0:57.6	So once you take that medication, the rate of the drug absorption can vary across the day and across the night.
1:06.7	Why is this?
1:08.0	In part it's because your circadian rhythm will alter the acids in your tummy. So
1:14.8	gastric acid secretion is regulated by the circadian rhythm. Your gastrointestinal motility,
1:22.9	meaning how effective is the gut at moving things through from start to finish. We also know that the blood flow,
1:31.1	the digestive tract, is altered. And all of these things can either change the speed or the slowness
1:39.0	with which those drugs are going to be absorbed. For example, with blood flow being higher in the morning hours,
1:47.1	as a result, there is going to be more absorption when the gastric emptying, as it were,
1:54.0	the speed of that processing is going to be faster. The next thing that circadian rhythms will do
	...

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