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🗓️ 18 December 2023
⏱️ 17 minutes
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Leaky gut symptoms go far beyond digestion. Let’s look at the 8 tell-tale signs of leaky gut that you’re likely overlooking.
What is Leaky Gut? https://drruscio.com/what-is-leaky-gut/
The Elemental Diet: An Effective Therapy for Gut Relief https://drruscio.com/elemental-diet/
The 4 Most Effective Leaky Gut Treatments: https://www.youtube.com/watch?v=MW1ezm3d0JQ&t=1092s
00:00 Intro
00:49 What leaky gut is & how it’s measured
03:08 The digestive symptoms
06:04 Body-wide (systemic) symptoms
Association between increased intestinal permeability and disease: A systematic review: https://www.sciencedirect.com/science/article/abs/pii/S221295881730160X#:~:text=Results,and%2017%E2%80%9365%25%20respectively.
Plasma and fecal zonulin are not altered by a high green leafy vegetable dietary intervention: secondary analysis of a randomized control crossover trial: https://pubmed.ncbi.nlm.nih.gov/35413837/
Specific Immunoglobulin E and G to Common Food Antigens and Increased Serum Zonulin in IBS Patients: A Single-Center Bulgarian Study: https://pubmed.ncbi.nlm.nih.gov/35466276/
Diet and intestinal bacterial overgrowth: Is there evidence?: https://pubmed.ncbi.nlm.nih.gov/35801041/
Relationship between Gut Microbiota, Gut Hyperpermeability and Obesity: https://pubmed.ncbi.nlm.nih.gov/32693755/
Leaky Gut and the Ingredients That Help Treat It: A Review: https://pubmed.ncbi.nlm.nih.gov/36677677/#:~:text=Thus%2C%20leaky%20gut%20syndrome%20and,diabetes%20mellitus%2C%20and%20celiac%20disease.
Cytokine-induced alterations of gastrointestinal motility in gastrointestinal disorders: https://pubmed.ncbi.nlm.nih.gov/22013552/
Serum zonulin is elevated in IBS and correlates with stool frequency in IBS-D: https://pubmed.ncbi.nlm.nih.gov/31210949/
The Role of Leaky Gut in Functional Dyspepsia: https://pubmed.ncbi.nlm.nih.gov/35422683/
Duodenal Mucosal Barrier in Functional Dyspepsia: https://pubmed.ncbi.nlm.nih.gov/34607017/
Gut dysbiosis in severe mental illness and chronic fatigue: a novel trans-diagnostic construct? A systematic review and meta-analysis: https://pubmed.ncbi.nlm.nih.gov/33558650/
Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome: https://pubmed.ncbi.nlm.nih.gov/27338587/
C-type lectin-like receptor 2 and zonulin are associated with mild cognitive impairment and Alzheimer's disease: https://pubmed.ncbi.nlm.nih.gov/31715011/
Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis: https://pubmed.ncbi.nlm.nih.gov/32332732/
Prevalence of sleep disorder in irritable bowel syndrome: A systematic review with meta-analysis: https://pubmed.ncbi.nlm.nih.gov/29652034/
Dysbiosis in food allergy and implications for microbial therapeutics: https://pubmed.ncbi.nlm.nih.gov/33463542/
Gut-Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions: https://pubmed.ncbi.nlm.nih.gov/33670115/
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DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.
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*Full transcript available on YouTube by clicking the “Show transcript” button on the bottom right of the video.
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0:00.0 | Welcome to Dr. Rousho Radio, providing practical and science-based solutions to feeling your best. |
0:17.2 | To stay up to date on the latest topics, as well as all of our prior episodes, make sure to |
0:22.5 | subscribe in your podcast player. For weekly updates, visit Dr.ruisho.com. That's d r-R-R-U-S-C-I-O.com. |
0:32.6 | The following discussion is for educational purposes only and is not intended to diagnose or treat any disease. |
0:39.4 | Please do not apply any of this information without first speaking with your doctor. Now, let's head to the show. |
0:46.1 | Hey everyone, let's discuss the most common symptoms of leaky gut. And this actually provides a pretty |
0:51.0 | powerful example of how important your gut health is, because when we look at the common symptoms of leaky gut, we see that they're not only digestive, |
0:58.1 | but they also go all the way to systemic symptoms that may impact the brain or your skin or even |
1:04.1 | your metabolism. So let's detail this, giving you a better understanding of what symptoms |
1:09.3 | might be driven by leaky gut. |
1:12.3 | Just in brief here to define leaky gut. |
1:14.7 | There's a few ways of measuring this. |
1:16.8 | I think the best is serum or blood zonulin or LPS, lipopolysaccharide. |
1:24.9 | Zonelin is a protein that tells you the function of the gate in the |
1:31.0 | intestinal wall that allows things through. And LPS are actual pieces of bacterial fragments |
1:39.8 | that can leak through. So these are the measures and they're both giving us |
1:45.2 | slightly different windows into measuring the amount of material that passes through |
1:51.2 | the lining most namely of the small intestine. Now you should have of course |
1:56.0 | quite a bit of stuff coming through because you want to absorb calories, |
2:00.1 | vitamins, nutrients, but there |
2:03.0 | is such a thing as too much. And this is when you have excessive leakage or permeability |
2:09.4 | and is leaky gut. From a prevalence perspective, some studies have done a pretty good job of summating how common is |
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