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🗓️ 14 March 2024
⏱️ 25 minutes
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Have you recently heard about Akkermansia and wondered what it's all about? Â
We know it’s a commensal bacteria that resides in the human gut, thriving in the mucus layer, but its popularity in the wellness world has many asking: Are the benefits truly substantial? Â
To answer this question let’s go over some common claims and what the research actually tells us.
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00:00Â IntroÂ
02:06Â What is Akkermansia?
04:29 “Only strain that lives and regulates the gut lining”
05:10 “Major part of the microbiome”
06:49 “Low levels are associated with poor gut health”
07:56 “Good for metabolism & gut health”Â
10:30 Beware of “Positive Publication Bias”
12:14Â Other probiotics that improve gut health
12:54Â Increasing Akkermansia naturally
17:49Â Key takeaways
18:54Â Recommended protocol
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Akkermansia muciniphila: 18 years after its first discovery https://www.frontiersin.org/articles/10.3389/fgstr.2022.1024393/full
Akkermansia muciniphila, a human intestinal mucin-degrading bacterium https://pubmed.ncbi.nlm.nih.gov/15388697/
Role of Akkermansia in Human Diseases: Â https://pubmed.ncbi.nlm.nih.gov/37111034/
Akkermansia muciniphila improves glucose homeostasis https://pubmed.ncbi.nlm.nih.gov/33820962/
Spatial Characteristics of Colonic Mucosa-Associated Gut Microbiota in Humans https://pubmed.ncbi.nlm.nih.gov/34223947/
Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression https://pubmed.ncbi.nlm.nih.gov/36835309/
Gut Bifidobacteria Populations in Human Health and Aging https://pubmed.ncbi.nlm.nih.gov/27594848/
Akkermansia muciniphila in the Human GI Tract https://pubmed.ncbi.nlm.nih.gov/30041463/
Intestinal Lactobacillus in health and disease, a driver or just along for the ride? https://pubmed.ncbi.nlm.nih.gov/28866243/
Akkermansia lower in severe obesity https://pubmed.ncbi.nlm.nih.gov/31265324/
Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes https://pubmed.ncbi.nlm.nih.gov/34085773/
Akkermansia muciniphila in IBD:Â https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853388/
Mucosa-Associated Microbiota in Patients with IBSÂ https://pubmed.ncbi.nlm.nih.gov/33271532/
Differences in the Composition of Gut Microbiota between Patients with Parkinson's Disease https://pubmed.ncbi.nlm.nih.gov/34884399/
Gut microbiome of MS patients https://pubmed.ncbi.nlm.nih.gov/36113426/
Probiotics fortify intestinal barrier function https://pubmed.ncbi.nlm.nih.gov/37168869/
Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in IBSÂ https://pubmed.ncbi.nlm.nih.gov/37686889/
Clinical effects and gut microbiota changes of using probiotics, prebiotics or synbiotics in IBDÂ https://pubmed.ncbi.nlm.nih.gov/33555375/
Effects of probiotics on functional constipation https://pubmed.ncbi.nlm.nih.gov/32005532/
Probiotics for Preventing and Treating SIBOÂ https://pubmed.ncbi.nlm.nih.gov/28267052/
Probiotics as an effective therapeutic approach in alleviating depression symptoms https://pubmed.ncbi.nlm.nih.gov/35348020/
Diets that differ in their FODMAP content alter the colonic luminal microenvironment https://pubmed.ncbi.nlm.nih.gov/25016597/
Prebiotic Effect on Gut With Altered FODMAP Intake in Patients with Crohn's Disease https://pubmed.ncbi.nlm.nih.gov/27077959/
Efficacy of a low FODMAP diet in IBSÂ https://pubmed.ncbi.nlm.nih.gov/34376515/
Lipoprotein and Endotoxemia Improvement in Metabolic Syndrome with Gut Microbiota Modification https://pubmed.ncbi.nlm.nih.gov/31451009/
Regulation of gut microbiome by keto diet https://pubmed.ncbi.nlm.nih.gov/36313018/
Islamic fasting leads to an increased Akkermansia https://pubmed.ncbi.nlm.nih.gov/31854308/
Strategies to promote Akkermansia https://pubmed.ncbi.nlm.nih.gov/30416539/
Adjuvant Probiotics Attenuate Glycemic Levels and Inflammatory Cytokines in Type 1 Diabetes Mellitus https://pubmed.ncbi.nlm.nih.gov/35299968/
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*Full transcript available on YouTube by clicking the “Show transcript” button on the bottom right of the video.
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0:00.0 | Welcome to Dr. Rousho Radio, providing practical and science-based solutions to feeling your best. |
0:15.4 | To stay up to date on the latest topics, as well as all of our prior episodes, make sure to subscribe in your podcast player. |
0:22.9 | For weekly updates, visit Dr. Russo.com. That's DRR-R-U-S-C-I-O.com. |
0:30.6 | The following discussion is for educational purposes only and is not intended to diagnose or treat |
0:36.4 | any disease. Please do not apply any of this information |
0:39.6 | without first speaking with your doctor. Now, let's head to the show. Hey everyone, let's discuss |
0:45.5 | Acrimanthia mucanophilia, a new probiotic and go over the claims, sort of juxtapose some of the claims about this probiotic against the evidence |
0:57.5 | and attempt to come away with a practical, reasonable, and scientifically informed perspective on acrimancia. |
1:06.0 | And just to share sort of my perspective going into reviewing the research here, I tend to be |
1:12.7 | constitutionally suspicious. And the reason for this is early my career, I may have had, |
1:19.9 | you could say, rose-colored glasses on, where I assumed everything in natural health was good |
1:26.1 | and effective and could do no harm. |
1:28.8 | And over the years, and upon fact-checking many products, claims, tests, etc., |
1:35.3 | I've more often than not become disappointed, which is why the perspective I take with you is one that's more guarded, |
1:45.3 | certainly open-minded, and wanting to explore any therapeutic that could alleviate suffering and optimize health. |
1:51.3 | But also seeing how many people can waste money or chase a frivolous diagnosis and suffer |
1:58.7 | sort of the psychological turmoil that is connected to that, |
2:02.4 | I try to be scrupulous with fact-checking the things that we discuss and delivering to you |
2:08.0 | a reasonable and evidenced-informed perspective when we have due evidence. As I've said many |
2:15.1 | a time, there are some areas in health care where there's not |
2:18.3 | much research and clinicians are kind of in the trenches, doing the best that they can, and trying |
2:23.3 | to take anecdotes and use those to inform how to practice. Nevertheless, let's review Ackermansia |
... |
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