Cholesterol and dementia | Dr Kellyann Niotis, Md and Dr Thomas Dayspring, Md

The Proof with Simon Hill

Simon Hill

Nutrition, Health & Fitness, Self-improvement, Education

4.9 • 2.9K Ratings

🗓️ 30 September 2024

⏱️ 131 minutes

🔗️ Recording | iTunes | RSS

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Summary

Episode #333. What does cholesterol have to do with dementia? Learn how to protect your brain health in the long term with this information you should be considering from your twenties and thirties. From cutting-edge science on cholesterol metabolism to fourteen key risk factors for dementia, we break down what you can do now to reduce your risk of cognitive decline later. In this episode, I’m joined by two renowned experts, Dr Kellyann Niotis and Dr Thomas Dayspring. Together, we explore the connection between cholesterol and dementia, personalised prevention strategies, and how making lifestyle changes today can safeguard your brain for the future. Specifically, we discuss: Intro (00:00) Cardiology Meets Neurology: Understanding the Connection (07:53) Dementia and Neurodegenerative Diseases: A Comprehensive Overview (13:26) Recognizing Early Dementia Signs and Risk Factors (21:43) Lipoproteins and Brain Health: The Crucial Link (32:36) ApoB vs ApoE: Comparing Apoprotein Functions in Neurological Health (44:24) APOE4 Carriers: Potential Therapeutic Approaches (01:00:30) ApoA1 and HDL: Their Role in Dementia Prevention (01:03:27) Genetic Testing for Dementia: Understanding APOE4 Implications (01:13:19) APOE4 Gene: Impact on Dementia Risk and Brain Health (01:17:58) Desmosterol's Role in Maintaining Brain Health (01:20:56) LDL Cholesterol: A Key Factor in Dementia Risk Assessment (01:34:05) APOE4: Comparing Single vs. Double Copy Risk Factors (01:39:15) Omega-3 Fatty Acids: Essential Nutrients for Brain Health (01:38:49) LDL Cholesterol Levels: Assessing Low vs. High Risk for Dementia (01:56:50) Key Takeaways: Preventive Neurology and Future Research Directions (02:00:10) Connect with Dr Kellyann Niotis at https://drkellyannniotis.com/ and discover research and resources at https://ind.org/. Connect with Dr Thomas Dayspring on Twitter/X or LinkedIn, and listen to his past appearances on The Proof here. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Shopify Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof. Birch Sleep deeply and wake up refreshed with a Birch Natural Mattress, combining premium natural materials with unbeatable comfort. Rest easy with a 100-night trial and 25-year warranty. Get 25% off all mattresses and 2 free pillows at birchliving.com/simonhill. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants

Transcript

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0:00.0	In today's episode I sit down with preventive neurologist Dr.
0:03.9	Kellyan Niodus and lipidologist Dr Thomas Dayspring to discuss what we can do
0:10.0	to prevent dementia.
0:12.1	Earlier this year the Lancet published a report summarizing 14
0:16.4	established risk factors that if addressed could prevent almost 50% of all cases of dementia. This report provides a clear
0:26.7	roadmap for what we should be doing, beginning from early life through midlife
0:31.0	and into late life to reduce our chances of having cognitive
0:34.9	impairment as we age. While we had originally planned to discuss all 14 of
0:40.6	these risk factors in this episode we ended up going quite deep on one of the 14 risk factors,
0:46.4	elevated LDL cholesterol, which made sense with Dr Day Spring joining us.
0:51.7	We covered a lot of territory. Why is elevated LDL
0:56.7	cholesterol a risk factor for dementia? How the brain produces its own cholesterol
1:02.3	separate to cholesterol throughout the
1:04.3	prophery how genetics specifically the two apoey genes that we all have one from
1:10.9	mom and one from dad affect cholesterol transport in the brain, and subsequently
1:16.6	risk of Alzheimer's dementia. How to know what ApoE genes you have? Why ApoE4 carriers may need more DHA, an important long chain
1:26.8	omega-3 fatty acid. Why eating cholesterol doesn't affect brain cholesterol levels.
1:32.1	Whether or not statins, which lower blood
1:35.2	cholesterol affect brain cholesterol and cognition, and a whole lot more. As is often the
1:42.0	case here at the proof, we went pretty deep. You guys know I love to get into the weeds.
1:48.0	And in a day and age where faster is better, that's something I hope you appreciate and benefit from.
1:55.9	That said I do understand that going into the weeds can often be a little frustrating and we need
	...

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