Everything you need to know about metabolic health | Metabolic Health Masterclass

The Proof with Simon Hill

Simon Hill

Nutrition, Health & Fitness, Self-improvement, Education

4.9 • 2.9K Ratings

🗓️ 2 September 2024

⏱️ 181 minutes

🔗️ Recording | iTunes | RSS

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Summary

Episode #329. Boost metabolic health and prevent disease with expert insights from an all-star lineup of scientists. Learn key strategies for improving metabolic health, including metabolic flexibility, muscle health, and the critical roles of diet and exercise in preventing type 2 diabetes and fatty liver disease. In this episode, you’ll hear from a distinguished panel of specialists including applied exercise physiologist Inigo San Millan, PhD; skeletal muscle expert Don Layman, PhD; type 2 diabetes authority Roy Taylor, PhD; dietitian and researcher Andrea Glenn, PhD, RD; nutrition scientist Alan Flanagan, PhD; nutrition scientist and endocrinologist Christos Mantzoros MD, DSc, PhD; and physician and researcher Richard Johnson, MD. Specifically, we discuss: Intro (00:00) What is Metabolic Health (01:35) Metabolic Health, Mitochondria, Defining 'Metabolise', Metabolic Flexibility (07:02) The Importance of Skeletal Muscle for Metabolic Health (20:03) Exercise for metabolic health ****Zone 2 (28:36) Twin Cycle Hypothesis (56:45) Understanding the Personal Fat Threshold (01:08:15) Summary of the DiRECT Trial: Examining the Twin Cycle Hypothesis with Roy Taylor (01:17:08) Are DASH, Nordic, Mediterranean, and Portfolio diets good for preventing and managing diabetes? (01:36:46) Understanding Non-Alcoholic Fatty Liver Disease and Its Development (01:42:39) The Science of Hepatic Fat Oxidation (01:49:37) Consequences and Effects of Fatty Liver Disease (01:55:14) Linking Non-Alcoholic Fatty Liver Disease with Type 2 Diabetes (02:00:42) Combination of Fructose and Saturated fat on Metabolic Health (02:13:21) Type of fat and its effect on Metabolic Health (02:17:35) What cause Metabolic Health: fat or fructose (02:24:01) New Fat Storage Mechanisms - Personal Fat Threshold (02:27:50) Modern Techniques for Accurate Body Fat Measurement (02:31:52) Health metabolic biomarkers (02:36:51) Ectopic fat (02:38:19) Fat storage and metabolic health (02:39:10) Evolutionary Insights into Human Fat Storage (02:42:02) Fatty Liver Disease (02:45:46) Outro (2:57:46) Connect with today’s guests and listen to their previous episodes at the links above. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. LMNT Stay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high-protein Plant Performance recipe book

Transcript

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0:00.0	Howdy friends? Welcome back. It's great to be hanging out again. In today's
0:04.2	masterclass we hear from a variety of expert voices on all things
0:09.2	metabolic health. What is metabolic health? What is metabolic health? What is metabolic flexibility? Why do people develop metabolic
0:16.1	conditions like type 2 diabetes and non-alcoholic fatty liver disease? How specific
0:22.0	types of exercise and nutrition can improve metabolic health, and much more.
0:28.0	In this episode, you'll hear from Professor Inigo San Milan, an expert in exercise science, metabolism and mitochondrial function.
0:35.9	Professor Don Lehman, an expert on all things skeletal muscle.
0:40.3	Professor Roy Taylor, an expert on type 2 diabetes, who's very well known for the twin
0:46.1	cycle model that we'll learn about. Dr Andrea Glenn, who researches how different dietary
0:52.0	patterns affect risk of developing metabolic conditions,
0:56.0	like type 2 diabetes. Dr. Alan Flanagan, who's a nutrition scientist that is very well versed in the way that different nutrients
1:04.6	affect the health of our liver and thus metabolic health.
1:08.2	Dr. Richard Johnson, whose research has focused on fatty liver disease and insulin resistance and of course crowd favorite
1:15.2	Professor Christos Manzoros a nutrition scientist and endocrinologist interested
1:21.0	in assessing preventing and treating metabolic health-related conditions.
1:25.0	This is really a treasure trove of information.
1:30.0	Please enjoy.
1:41.0	My favorite multivitamin by a long stretch is a meal's essential 8, the right nutrients and the right doses to support a healthy plant-rich diet,
1:45.6	optimize nutrient status, and leave you feeling at your best.
1:49.7	Take your health to another level with the meal's evidence-based essential 8
1:53.8	multivitamin by going to a meal.com forward slash Simon for 20% off your first
1:59.4	purchase and 10% off repeat purchases.
	...

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