Fenofibrate Pharmacology Podcast Episode 310
Real Life Pharmacology - Pharmacology Education for Health Care Professionals
Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist
5 • 716 Ratings
🗓️ 18 January 2024
⏱️ 13 minutes
🧾️ Download transcript
Summary
Fenofibrate is typically only used for hypertriglyceridemia. The primary risk of hypertriglyceridemia is pancreatitis so we treat these levels because of this risk.
LFTs elevation has been associated with fenofibrate use as well as myopathy. In the presence of myopathy, checking CPK may be considered.
Fenofibrate is a weak CYP2C9 inhibitor. Warfarin and phenytoin are two important medications that may be affected by the use of fenofibrate.
Transcript
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| 0:00.0 | Hey all, welcome back to the real-life pharmacology podcast. |
| 0:03.7 | I've got an exciting episode on phenofibrate today. |
| 0:07.2 | Before I get into that, make sure you go get your top 200 study guide, |
| 0:12.8 | 31-page PDF, absolutely free at real-life pharmacology.com. |
| 0:17.4 | Simply an email. |
| 0:18.6 | We'll get you access to that. |
| 0:22.4 | Great no-brainer if you're out in practice or if you're taking pharmacology classes definitely a lot of clinical pearls and a lot of |
| 0:28.0 | things that show up in practice as well as on board exam so again you can get that at real |
| 0:33.2 | life pharmacology dot com all right phenofibrate the drug of the day today. There's numerous brand names |
| 0:40.8 | of this medication, tricore, fibercore, trilopex, triglyde, lots of lots of different brand names, |
| 0:49.3 | and even a few more. So with that said, what is this medication used for? The number one use and probably the only |
| 0:58.1 | use I can think of, or that I comes to the top of my head, is elevated triglyceride, so hyper |
| 1:06.5 | triglyceridemia. Mechanistically, this medication is what's called a P-PAR alpha agonist, |
| 1:13.9 | which reduces apoprotein C, |
| 1:18.2 | which ultimately inhibits lipoprotein lipase. |
| 1:22.8 | Now, this all results in basically increased breakdown of cholesterol, such as VLDL, |
| 1:31.9 | and elimination of triglyceride-rich particles. So that's definitely kind of a mouthful |
| 1:38.6 | with the mechanism of action on pharmacology exams historically. |
| 1:45.1 | If you remember that it's a P-PAR alpha agonist, |
| 1:47.6 | usually that does enough to get you by |
| 1:50.3 | and be able to answer the question. |
| 1:53.5 | Dosing-wise, there are multiple dosage forms, |
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