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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Linagliptin Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 17 April 2025

⏱️ 11 minutes

🧾️ Download transcript

Summary

Today’s sponsor is Freed AI! Freed’s AI medical scribe listens, transcribes, and writes notes for you. Over 15,000 healthcare professionals use Freed and you should too! Learn more here!



On this episode of the Real Life Pharmacology Podcast, I cover linagliptin pharmacology, adverse effects, drug interactions, and much more.



Linagliptin is a DPP-4 inhibitor used to help control blood sugar levels in adults with type 2 diabetes. It works by increasing the levels of incretin hormones, which stimulate insulin release and decrease glucagon levels in the blood.



Linagliptin is usually taken once daily and can be used alone or in combination with other diabetes medications.



Unlike some other diabetes drugs, linagliptin does not usually cause weight gain or low blood sugar (hypoglycemia) when used alone.



Linagliptin should not be used with GLP-1 agonists as it works on a similar pathway as that medication class.

Transcript

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0:00.0

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0:07.1

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0:51.0

Hey all, welcome back to the real life pharmacologyology podcast. I am your host, pharmacist, Eric

0:56.1

Christensen, and I thank you so much for listening today. As always, go check out that top 200 study

1:02.6

guide. It's a 31-page PDF, absolutely no cost to you. Simply an email will get you access to that.

1:09.7

So that's at real-life pharmacology.com.

1:13.6

All right, the drug of the day today is Lyna Glyptin.

1:18.6

Brand name of this medication is Tragenta.

1:22.6

This is classified as a DPP4 inhibitor.

1:28.0

It has anti-diabetic activity, thus lowering blood sugars.

1:34.4

And mechanistically, how it does that is it inhibits dipeptidase 4.

1:42.5

That's the DPP4, which is much easier to say. So this is an enzyme, and ultimately,

1:49.5

by inhibiting this enzyme, we prolong the action of incritin. And if you remember from

1:59.0

GLP1 agonus, incritin is an important hormone in kind of the homeostasis of glucose, blood sugar, and those type of things.

2:10.3

So those incritin hormones, GLP1, and GIP, so that's glucose-dependent, insulinotropic polypeptide.

2:22.0

These regulate that glucose homeostasis, thus increasing insulin synthesis is one of their roles,

...

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