Prednisone Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5 • 716 Ratings

🗓️ 24 April 2025

⏱️ 17 minutes

🔗️ Recording | iTunes | RSS

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Summary

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Prednisone is a commonly used medication for its antiinflammatory and immunosuppressive action. On this episode I discuss prednisone pharmacology, ADRs, and much more.

In the episode, I discuss how prednisone affects the HPA system in the body. Cortisol production can be greatly impacted by long term use of prednisone.

GI adverse effects can be problematic with oral prednisone which is why we often give this medication with food or milk.

Hyperglycemia is a complication from the use of prednisone. I've commonly seen blood sugar spike by 50-100+ mg/dL due to this medication.

Osteoporosis is a long term risk with the use of prednisone. Prednisone can also impact the benefits of vaccination. I discuss this in greater depth in the drug interactions portion of the podcast.

Transcript

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0:50.8	Hey, all, welcome back to the Real Life Pharmacology podcast.
0:53.7	I'm your host pharmacist, Derek Christensen. Thank you so life pharmacology podcast. I'm your host pharmacist,
0:54.8	Eric Christensen. Thank you so much for listening today. I'm a little shocked. I've got an email
1:00.0	asking me to do a podcast on prednisone, and I totally anticipated. I've done that one, but I have
1:07.7	actually not done specifically prednisone. It is part of my top 200 list that I completed
1:15.3	a few weeks back, but today I'm going to get into prednisone. First, I wanted to mention, go check
1:22.9	out real-life pharmacology.com. Get your free 31-page PDF on the top 200 drugs.
1:28.4	Definitely a no-brainer to have that.
1:30.2	Simply an email will get you access.
1:32.8	So moving on, prednisone.
1:34.6	Very commonly used medication, brand name is delta zone.
1:39.1	This is classified as a corticosteroid.
1:43.1	Also could be classified as an immunosuppressant type medication,
1:48.2	anti-inflammatory type medication as well.
	...

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