Metronidazole Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5 • 716 Ratings

🗓️ 21 November 2019

⏱️ 11 minutes

🔗️ Recording | iTunes | RSS

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Summary

Metronidazole (Flagyl) is an antibiotic that is used for various infections.

Metronidazole can certainly cause GI upset like most antibiotics, but uniquely may also cause a metallic taste.

Metronidazole is also rarely associated with CNS changes and can induce the potential for peripheral neuropathy.

Patients should avoid alcohol with the use of metronidazole and this is on account for the possibility of a disulfiram reaction. I discuss some of the symptoms of this reaction in the podcast.

Metronidazole can substantially raise the concentrations of warfarin. INR monitor and a reduction in dose of warfarin may be necessary.

Transcript

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0:00.0	Hey all, welcome back to the Real Life Pharmacology podcast. I am your host, Eric Christensen,
0:06.0	pharmacist. And if you want to get in contact with me, LinkedIn is a good way to do that.
0:12.5	Eric Christensen, FarmD, B-C-GP, B-CPS, you can find me there. Also through the website,
0:20.0	real-life pharmacology.com. We've also got that free
0:23.4	giveaway, 31-page PDF on the top 200 drugs and their pharmacology and important clinical pearls
0:33.3	that you actually might come across in real life. So definitely go download that for free.
0:39.9	And obviously you also get updates
0:41.4	when we've got a new podcast or any other info to share for you there.
0:46.7	So go check that out at real life pharmacology.com.
0:50.5	For today, we're going to get into metronidazole the brand name of that medication is
0:57.0	flageal and this is an antibiotic for infection i do see it somewhat frequently i guess definitely
1:04.9	a good one to know to pay attention to being an antibiotic probably the most common uses for this medication,
1:14.2	bacterial vaginosis. Historically, C. diff was probably a lot more common for its use.
1:22.8	We have had changes in the guidelines, and now at least at this point, at the time I I'm making it vancomycin oral is typically going to be preferred there but still
1:33.9	remains an option if certain other options aren't available there intra-abdominal
1:40.1	infections in general metronidazole's got some good activity specifically against
1:47.7	anaerobic bacteria okay so that's an important little nugget to remember with
1:53.6	regards to the use and where you might see metronidazole used and kind of along
1:59.4	with that depending upon the type and surgery the type of surgery
2:04.6	and the location of surgery metronidazole might be used in prophylaxis again you know if you're
2:12.9	doing some sort of GI surgery where a bacteria gut bacteria are going to be in play.
2:19.6	We might use metroninazole because a lot of those bacteria are potentially susceptible to the drug.
	...

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