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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Testosterone Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 14 November 2019

⏱️ 11 minutes

🧾️ Download transcript

Summary

Testosterone replacement is primarily utilized in patients with hypogonadism. I discuss testosterone pharmacology, adverse effects, and drug interactions on this podcast episode.



Testosterone is a controlled substance because it is most often diverted for its potential to build muscle in athletes for competitive sports.



There is cardiovascular risks associated with the use of testosterone.



Testosterone can raise blood pressure and also raise cholesterol levels which may be a contributing factor to its potential to cause cardiovascular events.

Transcript

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0:00.0

Hey all, welcome back to the real life pharmacology podcast. I am your host, Eric Christensen.

0:06.8

And today I'm going to cover testosterone. So testosterone is a medication used primarily in the setting of hypogonadism.

0:19.0

So essentially, this is replacement, where patients are deficient in testosterone.

0:26.7

Now, from a mechanistic physiological standpoint, testosterone and its derivatives are found in the body.

0:37.0

They are classified as an androgen. its derivatives are found in the body.

0:40.4

They are classified as an androgen.

0:49.1

And androgens are really responsible for creating, maintaining male characteristics and the development of male sex organs.

0:53.2

Now, you've probably heard about steroids primarily through abuse.

0:59.6

If you follow sports, athletics, track and field, baseball, you name the sport.

1:05.4

And testosterone has probably been associated with it as a potential drug to be diverted. And in addition to,

1:17.0

you know, those male characteristics and formation of those male sex organs,

1:23.0

anabolic steroids like testosterone promote muscle building. you can imagine regardless of your sport if

1:31.4

you're bigger faster stronger there's potential for abuse of these agents so definitely keep that

1:41.3

in mind with testosterone for sure.

1:46.1

Now, one really unique thing about testosterone

1:50.1

and the commercially available products of testosterone,

1:55.7

is there are a ton of different drug formulations.

1:59.8

We've got intramuscular, we've got topical testosterone,

2:06.2

like gels and patches, oral, injectable,

2:10.6

as far as we've got subcutaneous pellets, for example,

2:15.2

that are kind of time-re release, delayed release of testosterone.

2:19.2

So multiple different avenues to deliver testosterone in those patients that needed.

...

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